Lipopolysaccharide inhibition of glucose production through the Toll‐like receptor‐4, myeloid differentiation factor 88, and nuclear factor κb pathway

Carl F. Raetzsch, Natasha L. Brooks, J. McKee Alderman, Kelli S. Moore, Peter A. Hosick, Simon Klebanov, Shizuo Akira, James E. Bear, Albert S. Baldwin, Nigel Mackman, Terry P. Combs – 29 July 2009 – Acute exposure to lipopolysaccharide (LPS) can cause hypoglycemia and insulin resistance; the underlying mechanisms, however, are unclear.

The impact of consecutive operations on survival after liver transplantation

Jeffrey B. Halldorson, Ramasamy Bakthavatsalam, Jorge D. Reyes, James D. Perkins – 29 July 2009 – The impact of surgeon fatigue on patient outcomes has not been previously studied. In order to assess the relationship of surgeon workload to patient outcome, we analyzed the impact of the interval between liver transplants and the cumulative number of liver transplants in a week on patient outcome. The outcomes of 390 liver transplants performed between 2003 and 2006 at the University of Washington Medical Center were analyzed.

The amazing universe of hepatic microstructure

Valeer J. Desmet – 29 July 2009 – An informal review is presented by the author of his 50 years of involvement in practice and research in hepatopathology. Some background for the author's attitude and meandering pathway into his professional career serves as introduction to a short discussion of the main topics of his interest and expertise. Histogenesis of liver cancer was the theme of early work for a Ph.D. thesis, the results of which were lost into oblivion due to local rules and circumstances, but were rescued three decades later.

Effect of alcoholic liver disease and hepatitis C infection on waiting list and posttransplant mortality and transplant survival benefit

Michael R. Lucey, Douglas E. Schaubel, Mary K. Guidinger, Santiago Tome, Robert M. Merion – 29 July 2009 – Disease‐specific analysis of liver transplant survival benefit, which encompasses both pre‐ and posttransplant events, has not been reported.

Late protocol liver biopsies in the liver allograft: A neglected investigation?

George Mells, Caroline Mann, Stefan Hubscher, James Neuberger – 29 July 2009 – As outcomes from liver transplantation have improved, attention has focused on long‐term outcomes: patient and graft survival is affected by many factors, including the consequences of both overimmunosuppression (eg, renal failure and cancer) and underimmunosuppression (eg, rejection). The use of protocol (rather than event‐driven) biopsies of the liver allograft, except for those grafted for HCV infection, has been largely abandoned.

Prognostic value of computerized quantification of liver fibrosis in children with biliary atresia

Lars Pape, Karen Olsson, Claus Petersen, Reinhard von Wasilewski, Michael Melter – 29 July 2009 – Biliary atresia (BA) is the leading indication for liver transplantation (LTx) during childhood. Predictive markers for progression are lacking. We investigated the correlation between quantified fibrosis of the liver at the time of Kasai hepatic portoenterostomy (KPE) and the clinical course. Liver tissue was obtained at the time of KPE in 53 children and stained with Picrosirius red. The mean volume of fibrosis per number of periportal fields (Vfib) and the Ishak score were calculated.

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