Ellen Hulskotte, Samir Gupta, Fengjuan Xuan, Marga van Zutven, Edward O'Mara, Hwa‐Ping Feng, John Wagner, Joan Butterton – 11 May 2012 – The hepatitis C virus protease inhibitor boceprevir is a strong inhibitor of cytochrome P450 3A4 and 3A5 (CYP3A4/5). Cyclosporine and tacrolimus are calcineurin inhibitor immunosuppressants used to prevent organ rejection after liver transplantation; both are substrates of CYP3A4. This two‐part pharmacokinetic interaction study evaluated boceprevir with cyclosporine (part 1) and tacrolimus (part 2).

Lijuan Liu, Xiaobei Chen, Shuixiang Xie, Chuanjie Zhang, Zhenpeng Qiu, Fan Zhu – 11 May 2012 – KIAA0101 overexpression was detected in numerous malignant solid tumors and involved in tumor progression; however, the correlation between KIAA0101 expression level and human hepatocellular carcinoma (HCC) was controversial.

Noriyo Yamashiki, Yasuhiko Sugawara, Sumihito Tamura, Nobuaki Nakayama, Makoto Oketani, Koji Umeshita, Shinji Uemoto, Satoshi Mochida, Hirohito Tsubouchi, Norihiro Kokudo – 11 May 2012 – Nationwide surveys of acute liver failure (ALF) are conducted annually in Japan, and 20% of patients with ALF undergo liver transplantation (LT). We extracted data for 212 patients who underwent LT for ALF from the nationwide survey database of the Intractable Liver Diseases Study Group of Japan.

Juan Rodés – 11 May 2012

Shinya Maekawa, Minoru Sakamoto, Mika Miura, Makoto Kadokura, Ryota Sueki, Kazuki Komase, Hiroko Shindo, Nobutoshi Komatsu, Kuniaki Shindo, Asuka Kanayama, Takako Ohmori, Fumitake Amemiya, Shinichi Takano, Tatsuya Yamaguchi, Yasuhiro Nakayama, Takatoshi Kitamura, Taisuke Inoue, Shunichi Okada, Nobuyuki Enomoto – 10 May 2012 – To comprehensively characterize the contribution of virological factors as well as interleukin‐28B (IL28B) single‐nucleotide polymorphisms (SNPs) in determining treatment responses in pegylated‐interferon plus ribavirin (Peg‐IFN/RBV) therapy for chronic hepatitis C vir

Edward William Holt – 10 May 2012

Marie Sinclair, Mathis Grossmann, Paul Gow, Peter Angus – 10 May 2012

Vincenzo Cardinale, Guido Carpino, Alfredo Cantafora, Lola M. Reid, Eugenio Gaudio, Domenico Alvaro – 10 May 2012

Anupama Raghuram, Alejandro Restrepo, Saman Safadjou, Jennifer Cooley, Mark Orloff, Dwight Hardy, Sam Butler, Christine E. Koval – 10 May 2012 – Invasive fungal infections (IFIs) are associated with a high mortality rate for liver transplantation (LT) recipients. To study the incidence of and risk factors for IFIs in LT recipients and the associated mortality rates, we retrospectively reviewed the records of first‐time deceased donor LT recipients (January 2003 to December 2007). The incidence of IFIs was 12%.

Masanobu Tsuda, Weici Zhang, Guo‐Xiang Yang, Koichi Tsuneyama, Yugo Ando, Kazuhito Kawata, Ogyi Park, Patrick S.C. Leung, Ross L. Coppel, Aftab A. Ansari, William M. Ridgway, Bin Gao, Zhe‐Xiong Lian, Richard Flavell, Xiao‐Song He, M.Eric Gershwin – 10 May 2012 – Mice with a dominant‐negative transforming growth factor β receptor restricted to T cells (dnTGFβRII mice) develop an inflammatory biliary ductular disease that strongly resembles human primary biliary cirrhosis (PBC).