Jihong Lian, Enhui Wei, Shu Pei Wang, Ariel D. Quiroga, Lena Li, Alba Di Pardo, Jelske van der Veen, Simonetta Sipione, Grant A. Mitchell, Richard Lehner – 18 June 2012 – Carboxylesterase 3/triacylglycerol hydrolase (Ces3/TGH) participates in hepatic very low‐density lipoprotein (VLDL) assembly and in adipose tissue basal lipolysis. Global ablation of Ces3/Tgh expression decreases serum triacylglycerol (TG) and nonesterified fatty acid levels and improves insulin sensitivity.

Hartmut Jaeschke, Mitchell R. McGill, C. David Williams – 18 June 2012

Philip Rosenthal – 18 June 2012

Bernhard Jäger, Andreas Drolz, Barbara Michl, Peter Schellongowski, Andja Bojic, Miriam Nikfardjam, Christian Zauner, Gottfried Heinz, Michael Trauner, Valentin Fuhrmann – 18 June 2012 – Hypoxic hepatitis (HH) is the most frequent cause of acute liver injury in critically ill patients. No clinical data exist about new onset of jaundice in patients with HH. This study aimed to evaluate the incidence and clinical effect of jaundice in critically ill patients with HH. Two hundred and six consecutive patients with HH were screened for the development of jaundice during the course of HH.

Milan J. Sonneveld, Willem P. Brouwer, Harry L.A. Janssen – 18 June 2012

Kimihiko Murase, Yuichi Chihara, Kenichi Takahashi, Shinya Okamoto, Hajime Segawa, Kazuhiko Fukuda, Koichi Tanaka, Shinji Uemoto, Michiaki Mishima, Kazuo Chin – 12 June 2012 – Noninvasive ventilation (NIV) refers to ventilation delivered through a noninvasive interface (a nasal or face mask) rather than an invasive interface (an endotracheal tube or tracheostomy). The role of NIV in preventing reintubation after abdominal surgery in pediatric patients is uncertain. Therefore, we evaluated the role of NIV for this purpose in pediatric patients after liver transplantation.

Olaf Neumann, Miriam Kesselmeier, Robert Geffers, Rossella Pellegrino, Bernhard Radlwimmer, Katrin Hoffmann, Volker Ehemann, Peter Schemmer, Peter Schirmacher, Justo Lorenzo Bermejo, Thomas Longerich – 11 June 2012 – To identify new tumor‐suppressor gene candidates relevant for human hepatocarcinogenesis, we performed genome‐wide methylation profiling and vertical integration with array‐based comparative genomic hybridization (aCGH), as well as expression data from a cohort of well‐characterized human hepatocellular carcinomas (HCCs).

Morris Sherman, Jordi Bruix, Michael Porayko, Tram Tran, for the AASLD Practice Guidelines Committee – 11 June 2012

Jyoti Srivastava, Ayesha Siddiq, Luni Emdad, Prasanna Kumar Santhekadur, Dong Chen, Rachel Gredler, Xue‐Ning Shen, Chadia L. Robertson, Catherine I. Dumur, Phillip B. Hylemon, Nitai D. Mukhopadhyay, Deepak Bhere, Khalid Shah, Rushdy Ahmad, Shah Giashuddin, Jillian Stafflinger, Mark A. Subler, Jolene J. Windle, Paul B. Fisher, Devanand Sarkar – 11 June 2012 – Astrocyte elevated gene‐1 (AEG‐1) is a key contributor to hepatocellular carcinoma (HCC) development and progression.

Xiong Cai, Jian Zhai, David E. Kaplan, Yijun Zhang, Lining Zhou, Xutao Chen, Guangyang Qian, Qiudong Zhao, Yonghai Li, Lu Gao, Wenming Cong, Minghua Zhu, Zhenlin Yan, Lehua Shi, Dong Wu, Lixin Wei, Feng Shen, Mengchao Wu – 9 June 2012 – Hepatic progenitor cells (HPC) play important roles in both liver regeneration and carcinogenesis. Combined hepatocellular‐cholangiocarcinoma (CHC), a malignant primary liver tumor with poor prognosis, is thought to be of HPC origin. However, the prognostic significance of this etiology is not well defined.