Living donor liver transplantation for hepatorenal syndrome: To do or not to do? That is the question
Mitra K. Nadim, Randall S. Sung – 27 June 2012
Severe muscle depletion in patients on the liver transplant wait list: Its prevalence and independent prognostic value
Puneeta Tandon, Michael Ney, Ivana Irwin, Mang M. Ma, Leah Gramlich, Vincent G. Bain, Nina Esfandiari, Vickie Baracos, Aldo J. Montano‐Loza, Robert P. Myers – 27 June 2012 – As detected by cross‐sectional imaging, severe muscle depletion, which is termed sarcopenia, holds promise for prognostication in patients with cirrhosis. Our aims were to describe the prevalence and predictors of sarcopenia in patients with cirrhosis listed for liver transplantation (LT) and to determine its independent prognostic significance for the prediction of waiting‐list mortality.
Rapid response activatable molecular probes for intraoperative optical image‐guided tumor resection
Samuel Achilefu – 26 June 2012
Investigation of residual hepatitis C virus in presumed recovered subjects
Kei Fujiwara, Robert D. Allison, Richard Y. Wang, Patricia Bare, Kentaro Matsuura, Cathy Schechterly, Krishna Murthy, Francesco M. Marincola, Harvey J. Alter – 23 June 2012 – Recent studies have found hepatitis C virus (HCV) RNA in peripheral blood mononuclear cells (PBMCs) of the majority of presumed recovered subjects. We investigated this unexpected finding using samples from patients whose HCV RNA and anti‐HCV status had been serially confirmed. HCV RNA was detected in PBMCs from 66 of 67 chronic HCV carriers.
Use of higher thromboelastogram transfusion values is not associated with greater blood loss in liver transplant surgery
Shen‐Chih Wang, Ho‐Tien Lin, Kuang‐Yi Chang, M. Susan Mandell, Chien‐Kun Ting, Ya‐Chun Chu, Che‐Chuan Loong, Kwok‐Hon Chan, Mei‐Yung Tsou – 23 June 2012 – Plasma‐containing products are given during the pre‐anhepatic stage of liver transplant surgery to correct abnormal thromboelastogram (TEG) values and prevent blood loss due to coagulation defects. However, evidence suggests that abnormal TEG results do not always predict bleeding. We questioned what effect using higher TEG values to initiate treatment would have on blood loss.
Reply
Salvatore Petta, Antonio Craxì – 22 June 2012
The risk association between experimental portal hypertension and an aortic atherosclerosis‐like disease
Natalia De las Heras, Maria‐Angeles Aller, Jaime Arias, Vicente Lahera – 22 June 2012
Hepatic progenitor cells: Another piece in the nonalcoholic fatty liver disease puzzle
Dawn M. Torres, Stephen A. Harrison – 22 June 2012
Hepatocyte‐specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice
Prachi Borude, Genea Edwards, Chad Walesky, Feng Li, Xiaochao Ma, Bo Kong, Grace L. Guo, Udayan Apte – 22 June 2012 – Farnesoid X receptor (FXR), the primary bile acid–sensing nuclear receptor, also plays a role in the stimulation of liver regeneration. Whole body deletion of FXR results in significant inhibition of liver regeneration after partial hepatectomy (PHX). FXR is expressed in the liver and intestines, and recent reports indicate that FXR regulates a distinct set of genes in a tissue‐specific manner.