Greg C. G. Hugenholtz, Jelle Adelmeijer, Joost C. M. Meijers, Robert J. Porte, R. Todd Stravitz, Ton Lisman – 6 March 2013 – Emerging evidence supports the concept of a rebalanced hemostatic state in liver disease as a result of a commensurate decline in prohemostatic and antihemostatic drivers. In the present study, we assessed levels and functionality of the platelet‐adhesive protein von Willebrand factor (VWF) and its cleaving protease ADAMTS13 in the plasma of patients with acute liver injury and acute liver failure (ALI/ALF).

Laura Capitaine, Kristof Thys, Kristof Assche, Sigrid Sterckx, Guido Pennings – 5 March 2013 – For many patients, living donor liver transplantation represents their only hope of receiving a lifesaving graft. In certain (albeit rare) cases, a minor will be the only suitable donor. Living liver donation by minors has been reported in several countries. In the academic literature and professional guidelines, little attention is paid to the development of an ethical framework for this practice. The focus is frequently limited to the donation of regenerative tissues and kidneys.

Changqing Ma, Jeffrey S. Crippin, William C. Chapman, Kevin Korenblat, Neeta Vachharajani, Kristen L. Gunter, Elizabeth M. Brunt – 5 March 2013 – Hepatopulmonary syndrome (HPS) and portopulmonary hypertension (PPH) are distinct pulmonary vascular complications of cirrhosis. Little is known about possible associated hepatic histopathological features.

Jens Martin Werner, Theo Heller, Ann Marie Gordon, Arlene Sheets, Averell H. Sherker, Ellen Kessler, Kathleen S. Bean, M'Lou Stevens, James Schmitt, Barbara Rehermann – 5 March 2013 – Hepatitis C virus (HCV) infection typically results in chronic disease with HCV outpacing antiviral immune responses. Here we asked whether innate immune responses are induced in healthcare workers who are exposed to small amounts of HCV, but do not develop systemic infection and acute liver disease.

Eun Sung Park, Ju‐Seog Lee – 5 March 2013

Yun‐Fan Liaw – 5 March 2013

Riccardo Superina – 5 March 2013

Diren Beyoğlu, Sandrine Imbeaud, Olivier Maurhofer, Paulette Bioulac‐Sage, Jessica Zucman‐Rossi, Jean‐François Dufour, Jeffrey R. Idle – 5 March 2013 – Hepatocellular carcinoma (HCC) is one of the commonest causes of death from cancer. A plethora of metabolomic investigations of HCC have yielded molecules in biofluids that are both up‐ and down‐regulated but no real consensus has emerged regarding exploitable biomarkers for early detection of HCC. We report here a different approach, a combined transcriptomics and metabolomics study of energy metabolism in HCC.

Bruce A. Runyon – 5 March 2013

Annika Mutanen, Jouko Lohi, Päivi Heikkilä, Antti I. Koivusalo, Risto J. Rintala, Mikko P. Pakarinen – 4 March 2013 – The aim of this study was to evaluate the long‐term effects of pediatric intestinal failure (IF) on liver histology. Altogether, 38 IF patients (median age: 7.2 years; range, 0.2‐27) underwent liver biopsy, gastroscopy, abdominal ultrasound, and laboratory tests. Sixteen patients were on parenteral nutrition (PN) after 74 PN months (range, 2.5‐204). Twenty‐two had weaned off PN 8.8 years (range, 0.3‐27) earlier, after 35 PN months (range, 0.7‐250).