Prediction models of long‐term Cirrhosis and hepatocellular carcinoma risk in chronic hepatitis B patients: Risk scores integrating host and virus profiles

Mei‐Hsuan Lee, Hwai‐I. Yang, Jessica Liu, Richard Batrla‐Utermann, Chin‐Lan Jen, Uchenna H. Iloeje, Sheng‐Nan Lu, San‐Lin You, Li‐Yu Wang, Chien‐Jen Chen, R.E.V.E.A.L.‐HBV Study Group – 15 March 2013 – Integrating host and HBV characteristics, this study aimed to develop models for predicting long‐term cirrhosis and hepatocellular carcinoma (HCC) risk in chronic hepatitis B virus (HBV) patients.

High prevalence of vitamin A deficiency and vitamin D deficiency in patients evaluated for liver transplantation

Mukund Venu, Eric Martin, Kia Saeian, Samer Gawrieh – 14 March 2013 – Deficiencies in vitamins A, D, and E have been linked to night blindness, bone health, and post–liver transplant reperfusion injury. The aim of this study was to determine the prevalence and predictive factors of fat‐soluble vitamin deficiencies in liver transplant candidates. We reviewed the medical records of liver transplant candidates at our center from January 2008 to September 2011.

Development, management, and resolution of biliary complications after living and deceased donor liver transplantation: A report from the adult‐to‐adult living donor liver transplantation cohort study consortium

Michael A. Zimmerman, Talia Baker, Nathan P. Goodrich, Chris Freise, Johnny C. Hong, Sean Kumer, Peter Abt, Adrian H. Cotterell, Benjamin Samstein, James E. Everhart, Robert M. Merion – 11 March 2013 – Adult recipients of living donor liver transplantation (LDLT) have a higher incidence of biliary complications than recipients of deceased donor liver transplantation (DDLT). Our objective was to define the intensity of the interventions and the time to resolution after the diagnosis of biliary complications after liver transplantation.

Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β‐Catenin signaling

Dan Xu, Fu Yang, Ji‐hang Yuan, Ling Zhang, Hai‐shan Bi, Chuan‐chuan Zhou, Feng Liu, Fang Wang, Shu‐han Sun – 11 March 2013 – In recent years, long noncoding RNAs (lncRNAs) have been investigated as a new class of regulators of biological function. A recent study reported that lncRNAs control cell proliferation in hepatocellular carcinoma (HCC). However, the role of lncRNAs in liver regeneration and the overall mechanisms remain largely unknown.

Genome‐wide screening reveals that miR‐195 targets the TNF‐α/NF‐κB pathway by down‐regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma

Jie Ding, Shenglin Huang, Ying Wang, Qi Tian, Ruopeng Zha, Haibing Shi, Qifeng Wang, Chao Ge, Taoyang Chen, Yingjun Zhao, Linhui Liang, Jinjun Li, Xianghuo He – 11 March 2013 – Nuclear factor kappa B (NF‐κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high‐throughput luciferase reporter screen that NF‐κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF‐κB signaling nodes by binding to their 3′ untranslated region (UTR).

Management and long‐term consequences of portal vein thrombosis after liver transplantation in children

M. Kyle Jensen, Kathleen M. Campbell, Maria H. Alonso, Jaimie D. Nathan, Frederick C. Ryckman, Greg M. Tiao – 11 March 2013 – Portal vein thrombosis (PVT) occurs in ≤12% of pediatric recipients of liver transplantation (LT). Known complications of PVT include portal hypertension, allograft loss, and mortality. The management of PVT is varied. A single‐center, case‐control study of pediatric LT recipients with portal vein (PV) changes after LT was performed.

Conversion from twice daily tacrolimus to once daily tacrolimus in long‐term stable liver transplant recipients: A single‐center experience with 394 patients

Jérôme Dumortier, Olivier Guillaud, Olivier Boillot – 8 March 2013 – After organ transplantation, strategies for simplifying the therapeutic regimen may improve adherence and prevent acute organ rejection and/or late graft loss. The aim of the present study was to evaluate the safety and efficacy of conversion from a tacrolimus (TAC) twice daily (bid) formulation to a once daily (qd) formulation in a large cohort of adult liver transplantation (LT) patients.

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