Blockade of CD47‐mediated cathepsin S/protease‐activated receptor 2 signaling provides a therapeutic target for hepatocellular carcinoma

Terence Kin‐Wah Lee, Vincent Chi‐Ho Cheung, Ping Lu, Eunice Yuen Ting Lau, Stephanie Ma, Kwan Ho Tang, Man Tong, Jessica Lo, Irene Oi Lin Ng – 12 February 2014 – Identification of therapeutic targets against tumor‐initiating cells (TICs) is a priority in the development of new therapeutic paradigms against cancer. We enriched a TIC population capable of tumor initiation and self‐renewal by serial passages of hepatospheres with chemotherapeutic agents. In chemoresistant hepatospheres, CD47 was found to be up‐regulated, when compared with differentiated progenies.

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