Hepatology highlights
Jean‐François Dufour – 25 February 2014
Nitrosative stress does not change during orthotopic liver transplantation
Dimitrios Tsikas, Jürgen C. Frölich, Jürgen Klempnauer, Thomas Becker – 25 February 2014
Hepatology highlights
Jean‐François Dufour – 25 February 2014
HCV genotype 3 is associated with an increased risk of cirrhosis and hepatocellular cancer in a national sample of U.S. Veterans with HCV
Fasiha Kanwal, Jennifer R. Kramer, Jawad Ilyas, Zhigang Duan, Hashem B. El‐Serag – 24 February 2014 – Data show that viral genotype 1 may increase the risk of cirrhosis and hepatocellular carcinoma (HCC) compared to genotype 2 in patients with chronic hepatitis C virus (HCV) infection. However, the effect of HCV genotype 3 on cirrhosis and HCC risk is uncertain. We identified patients with active HCV infection, confirmed by positive polymerase chain reaction (PCR) and a known HCV genotype, from the VA HCV Clinical Case Registry between 2000 and 2009.
Gd‐EOB‐DTPA‐enhanced magnetic resonance imaging and alpha‐fetoprotein predict prognosis of early‐stage hepatocellular carcinoma
Taro Yamashita, Azusa Kitao, Osamu Matsui, Takehiro Hayashi, Kouki Nio, Mitsumasa Kondo, Naoki Ohno, Tosiaki Miyati, Hikari Okada, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Yasuni Nakanuma, Hiroyuki Takamura, Tetsuo Ohta, Yasunari Nakamoto, Masakazu Yamamoto, Tadatoshi Takayama, Shigeki Arii, XinWei Wang, Shuichi Kaneko – 23 February 2014 – The survival of patients with hepatocellular carcinoma (HCC) is often individually different even after surgery for early‐stage tumors.
NRF2, not always friendly but perhaps misunderstood
George K. Michalopoulos – 23 February 2014
Novel labeling approaches for the assessment of human hepatic metabolism by in vivo magnetic resonance spectroscopy
Martin Krššák – 23 February 2014
Ribavirin improves the IFN‐γ response of natural killer cells to IFN‐based therapy of hepatitis C virus infection
Jens M. Werner, Elisavet Serti, Xenia Chepa‐Lotrea, Jonathan Stoltzfus, Golo Ahlenstiel, Mazen Noureddin, Jordan J. Feld, T. Jake Liang, Yaron Rotman, Barbara Rehermann – 23 February 2014 – Ribavirin (RBV) is an important component of interferon (IFN)‐based and direct antiviral treatment regimens for hepatitis C virus (HCV) infection. Immunomodulation, in particular improvement of the host IFN response, has been proposed as RBV's mechanism of action.
Systemic protection through remote ischemic preconditioning is spread by platelet‐dependent signaling in mice
Christian E. Oberkofler, Perparim Limani, Jae‐Hwi Jang, Andreas Rickenbacher, Kuno Lehmann, Dimitri A. Raptis, Udo Ungethuem, Yinghua Tian, Kamile Grabliauskaite, Rok Humar, Rolf Graf, Bostjan Humar, Pierre‐Alain Clavien – 23 February 2014 – Remote ischemic preconditioning (RIPC), the repetitive transient mechanical obstruction of vessels at a limb remote to the operative site, is a novel strategy to mitigate distant organ injury associated with surgery.
Progression of autoimmune hepatitis is mediated by IL‐18‐producing dendritic cells and hepatic CXCL9 expression in mice
Aki Ikeda, Nobuhiro Aoki, Masahiro Kido, Satoru Iwamoto, Hisayo Nishiura, Ryutaro Maruoka, Tsutomu Chiba, Norihiko Watanabe – 23 February 2014 – Clinical manifestations of autoimmune hepatitis (AIH) range from mild chronic to acute, sometimes fulminant hepatitis. However, it is unknown how the progression to fatal hepatitis occurs. We developed a mouse model of fatal AIH by inducing a concurrent loss of forkhead box P3+ regulatory T cells and programmed cell death‐1 (PD‐1)‐mediated signaling.