Variants of the inosine triphosphate pyrophosphatase gene and relapse risk following treatment for HCV genotype 2/3
Chia‐Yen Dai, Wan‐Long Chuang, Ming‐Lung Yu – 4 March 2014
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Martin Lagging, Karolina Rembeck, Jesper Waldenström, Staffan Nilsson, Kristina Nyström, Anna Martner, Magnus Lindh, Gunnar Norkrans, Johan Westin, Court Pedersen, Martti Färkkilä, Nina Langeland, Mads Rauning Buhl, Kristine Mørch, Peer B. Christensen, Kristoffer Hellstrand – 4 March 2014
Historical, present, and future significance of corticosteroid in the treatment of acute liver failure
Keiichi Fujiwara, Shin Yasui, Osamu Yokosuka – 4 March 2014
FDA bridging analyses confirmed in clinical trial
Poonam Mishra, Jeffry Florian, Jeffrey Murray – 2 March 2014
Treatment of phenylketonuria using minicircle‐based naked‐DNA gene transfer to murine liver
Hiu Man Viecelli, Richard P. Harbottle, Suet Ping Wong, Andrea Schlegel, Marinee K. Chuah, Thierry VandenDriessche, Cary O. Harding, Beat Thöny – 28 February 2014 – Host immune response to viral vectors, persistence of nonintegrating vectors, and sustained transgene expression are among the major challenges in gene therapy. To overcome these hurdles, we successfully used minicircle (MC) naked‐DNA vectors devoid of any viral or bacterial sequences for the long‐term treatment of murine phenylketonuria, a model for a genetic liver defect.
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Teresa Antonia Santantonio, Massimo Fasano, Evangelista Sagnelli – 28 February 2014
Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes
David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal – 28 February 2014 – Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM.
The influence of menopause on the development of hepatic fibrosis in nonobese women with nonalcoholic fatty liver disease
Masato Yoneda, Emmanuel Thomas, Yoshio Sumida, Yuichiro Eguchi, Eugene R. Schiff – 28 February 2014
Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes
David J. Harman, Philip V. Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad P. Aithal – 28 February 2014 – Although a higher prevalence of raised liver enzymes and altered echotexture on ultrasound have been reported in patients with type 1 diabetes mellitus (T1DM), the histological spectrum and natural history of chronic liver disease (CLD) in T1DM is unknown. We investigated the prevalence and outcome of histologically proven CLD in a longitudinal cohort of patients with T1DM.
Polysialic acid/neural cell adhesion molecule modulates the formation of ductular reactions in liver injury
Atsunori Tsuchiya, Wei‐Yu Lu, Birgit Weinhold, Luke Boulter, Benjamin M. Stutchfield, Michael J. Williams, Rachel V. Guest, Sarah E. Minnis‐Lyons, Alison C. MacKinnon, David Schwarzer, Takafumi Ichida, Minoru Nomoto, Yutaka Aoyagi, Rita Gerardy‐Schahn, Stuart J. Forbes – 28 February 2014 – In severe liver injury, ductular reactions (DRs) containing bipotential hepatic progenitor cells (HPCs) branch from the portal tract. Neural cell adhesion molecule (NCAM) marks bile ducts and DRs, but not mature hepatocytes.