Diagnosis of sinusoidal obstruction syndrome by positron emission tomography/computed tomography: Report of two cases treated by defibrotide

Mathieu Gauthé, Laurence Bozec, Pierre Bedossa – 17 March 2014 – Sinusoidal obstruction syndrome (SOS) is a potentially fatal liver injury that mainly occurs after myeloablative chemotherapy. We report two cases of SOS investigated by 18F‐fluorodeoxyglucose positron emission tomography/computed tomography and treated with defibrotide. (Hepatology 2014;60:1789–1791)

Recurrence of primary sclerosing cholangitis in pediatric liver transplant recipients

Veena L. Venkat, Sarangarajan Ranganathan, George V. Mazariegos, Qing Sun, Rakesh Sindhi – 17 March 2014 – There is little detailed clinical information on recurrent primary sclerosing cholangitis (rPSC) after liver transplantation in children. Our purpose was to describe the characteristics of children who had experienced rPSC after liver transplantation so that we could identify potential risk factors for recurrence.

Intraoperative hemodialysis during liver transplantation: A decade of experience

Mitra K. Nadim, Wanwarat Annanthapanyasut, Lea Matsuoka, Kari Appachu, Mark Boyajian, Lingyun Ji, Ashraf Sedra, Yuri S. Genyk – 17 March 2014 – Liver transplantation (LT) for patients with renal dysfunction is frequently complicated by major fluid shifts, acidosis, and electrolyte and coagulation abnormalities. Continuous renal replacement therapy (CRRT) has been previously shown to ameliorate these problems. We describe the safety and clinical outcomes of intraoperative hemodialysis (IOHD) during LT for a group of patients with high Model for End‐Stage Liver Disease (MELD) scores.

Epigenetics in liver disease

Derek A. Mann – 16 March 2014 – Epigenetics is a term that encompasses a variety of regulatory processes that are able to crosstalk in order to influence gene expression and cell phenotype in response to environmental cues. A deep understanding of epigenetics offers the potential for fresh insights into the basis for complex chronic diseases and improved diagnostic and prognostic tools.

Epigenetics in liver disease

Derek A. Mann – 16 March 2014 – Epigenetics is a term that encompasses a variety of regulatory processes that are able to crosstalk in order to influence gene expression and cell phenotype in response to environmental cues. A deep understanding of epigenetics offers the potential for fresh insights into the basis for complex chronic diseases and improved diagnostic and prognostic tools.

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