Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice

Irene Locatelli, Salvatore Sutti, Aastha Jindal, Marco Vacchiano, Cristina Bozzola, Chris Reutelingsperger, Dennis Kusters, Stefania Bena, Maurizio Parola, Claudia Paternostro, Elisabetta Bugianesi, Simon McArthur, Emanuele Albano, Mauro Perretti – 25 March 2014 – Annexin A1 (AnxA1) is an effector of the resolution of inflammation and is highly effective in terminating acute inflammatory responses. However, its role in chronic settings is less investigated.

Liver transplantation and cirrhotomimetic hepatocellular carcinoma: Classification and outcomes

Erica F. Clayton, Saloni Malik, Alexander Bonnel, Yifei Mu, Kim Olthoff, Abraham Shaked, Peter L. Abt, Heather Peterman, K. Rajender Reddy, Shane Ottmann, Emma E. Furth, Matthew H. Levine – 25 March 2014 – Liver transplantation has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC) that falls within certain size and numerical criteria for patients with cirrhosis. Cirrhotomimetic (CMM) HCC is an uncommon growth pattern that infiltrates cirrhotic parenchyma, can become extensive in size, and can evade detection via radiological studies.

Suppression of autophagy during liver regeneration impairs energy charge and hepatocyte senescence in mice

Takeo Toshima, Ken Shirabe, Takasuke Fukuhara, Toru Ikegami, Tomoharu Yoshizumi, Yuji Soejima, Tetsuo Ikeda, Shinji Okano, Yoshihiko Maehara – 25 March 2014 – Autophagy is a homeostatic mechanism that regulates protein and organelle turnover and uses the amino acids from degraded proteins to produce adenosine 5'‐triphosphate (ATP). We investigated the activity of autophagy‐associated pathways in liver regeneration after partial hepatectomy (PHx) in liver‐specific autophagy‐related gene 5 (Atg5) knockout (KO) mice.

Hepatic venous congestion in living donor grafts in liver transplantation: Is there an effect on hepatocellular carcinoma recurrence?

Suk‐Won Suh, Jeong‐Moo Lee, Tae You, Young Rok Choi, Nam‐Joon Yi, Kwang‐Woong Lee, Kyung‐Suk Suh – 25 March 2014 – A certain degree of graft congestion in living donor liver transplantation (LDLT) using a right liver graft may be inevitable because of the mismatch between the inflow and outflow structures of the liver. The subsequent inflammatory reaction and rapid regeneration of the graft have been suggested as causes of tumor recurrence. Therefore, we investigated the influence of graft congestion on hepatocellular carcinoma (HCC) recurrence after LDLT.

The impact of left ventricular hypertrophy on survival in candidates for liver transplantation

Sachin Batra, Victor I. Machicao, John S. Bynon, Shivang Mehta, Rajasekhar Tanikella, Michael J. Krowka, Steven Zacks, James Trotter, Kari E. Roberts, Robert S. Brown, Steven M. Kawut, Michael B. Fallon, for the Pulmonary Vascular Complications of Liver Disease Group – 22 March 2014 – Left ventricular hypertrophy (LVH) occurs in 12% to 30% of patients with cirrhosis; however, its prognostic significance is not well studied. We assessed the association of LVH with survival in patients undergoing a liver transplantation (LT) evaluation.

Etiology and management of hepatic artery thrombosis after adult liver transplantation

Moustafa Mabrouk Mourad, Christos Liossis, Bridget K. Gunson, Hynek Mergental, John Isaac, Paolo Muiesan, Darius F. Mirza, M. Thamara P. R. Perera, Simon R. Bramhall – 21 March 2014 – Hepatic artery thrombosis (HAT) represents a major cause of graft loss and mortality after liver transplantation. It occurs in up to 9% of adult recipients. The early diagnosis of HAT decreases septic complications, multiorgan failure, and graft loss, and there are better outcomes after treatment.

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