Liver Disease in the young adult with cystic fibrosis
Deirdre Kelly – 24 October 2014 – Watch a video presentation of this article
FSP27β, a novel fat‐specific protein 27 isoform promoting hepatic steatosis
Vishwajeet Puri – 21 October 2014
Systems biological analyses reveal the hepatitis C virus (HCV)‐specific regulation of hematopoietic development
Victoria M. Velazquez, Luke S. Uebelhoer, Manoj Thapa, Chris C. Ibegbu, Cynthia Courtney, Steven E. Bosinger, Joseph F. Magliocca, Andrew B. Adams, Allan D. Kirk, Stuart J. Knechtle, Daniel Kalman, Mehul S. Suthar, Arash Grakoui – 21 October 2014 – Chronic liver disease is characterized by the liver enrichment of myeloid dendritic cells (DCs). To assess the role of disease on myelopoiesis, we utilized a systems biology approach to study development in liver‐resident cells expressing stem cell marker CD34.
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Patrick Starlinger, Mickael Lesurtel, Christine Brostjan, Pierre‐Alain Clavien, Thomas Gruenberger – 21 October 2014
Predictive value of indocyanine green retention test and indocyanine green clearance in Child‐Pugh class A patients
Marie‐Louise Lindberg Pind, Søren Møller, Nasrin Faqir, Flemming Bendtsen – 20 October 2014
Management of bleeding and transfusion during liver transplantation before and after the introduction of a rotational thromboelastometry–based algorithm
Stéphanie Roullet, Geneviève Freyburger, Maximilien Cruc, Alice Quinart, Laurent Stecken, Magali Audy, Laurence Chiche, François Sztark – 20 October 2014 – Orthotopic liver transplantation (OLT) remains a potentially hemorrhagic procedure. Rotational thromboelastometry (ROTEM) is a point‐of‐care device used to monitor coagulation during OLT. Whether it allows blood loss and transfusions to be reduced during OLT remains controversial. Excellent correlations and predictive values have been found between ROTEM parameters and fibrinogen.
Patient preferences about organ offers in liver transplantation
Michael L. Volk – 20 October 2014
Cyclic adenosine monophosphate–responsive element modulator alpha overexpression impairs function of hepatic myeloid‐derived suppressor cells and aggravates immune‐mediated hepatitis in mice
Linda Hammerich, Klaudia Theresa Warzecha, Martina Stefkova, Matthias Bartneck, Kim Ohl, Nikolaus Gassler, Tom Luedde, Christian Trautwein, Klaus Tenbrock, Frank Tacke – 20 October 2014 – Molecular factors driving immune‐mediated inflammation in the liver are incompletely understood. The transcription factor, cyclic adenosine monophosphate‐responsive element modulator alpha (CREMα) can endorse differentiation of T lymphocytes toward T‐helper (Th)17 cells, thereby promoting autoimmunity in systemic lupus erythematosus or lung inflammation.
Development and validation of a “capture‐fusion” model to study drug sensitivity of patient‐derived hepatitis C
Morven E. Cunningham, Alia Javaid, Jenny Waters, Joseph Davidson‐Wright, Joshua L.C. Wong, Meleri Jones, Graham R. Foster – 20 October 2014 – Emerging therapies for chronic hepatitis C viral (HCV) infection involve inhibition of viral enzymes with drug combinations. Natural, or treatment‐induced, enzyme polymorphisms reduce efficacy. We developed a phenotyping assay to aid drug selection based on viral transfer from monocytes to hepatocytes.
Glycemic responses to intermittent hepatic inflow occlusion in living liver donors
Sangbin Han, Justin Sangwook Ko, Sang‐Man Jin, Jong Man Kim, Soo Joo Choi, Jae‐Won Joh, Yang Hoon Chung, Suk‐Koo Lee, Mi Sook Gwak, Gaabsoo Kim – 20 October 2014 – The occurrence of glycemic disturbances has been described for patients undergoing intermittent hepatic inflow occlusion (IHIO) for tumor removal. However, the glycemic responses to IHIO in living liver donors are unknown. This study investigated the glycemic response to IHIO in these patients and examined the association between this procedure and the occurrence of hyperglycemia (blood glucose > 180 mg/dL).