Impact of multiple transarterial chemoembolization treatments on hepatocellular carcinoma for patients awaiting liver transplantation

Eleonora Terzi, W. Ray Kim, William Sanchez, Michael R. Charlton, Paul Schmeltzer, Gregory J. Gores, James C. Andrews, Thomas C. Smyrk, Julie K. Heimbach – 5 November 2014 – Transarterial chemoembolization (TACE) is a common treatment for patients with hepatocellular carcinoma (HCC) who are awaiting liver transplantation (LT). The aim of this study was to assess the impact of multiple TACE treatments on tumor necrosis, tumor recurrence, and survival in these patients.

Hemostatic status in liver transplantation: Association between preoperative procoagulants/anticoagulants and postoperative hemorrhaging/thrombosis

Nobuhisa Akamatsu, Yasuhiko Sugawara, Akiko Nakazawa, Yujiro Nishioka, Junichi Kaneko, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo – 5 November 2014 – The delicate rebalanced hemostatic status of liver transplant recipients may lead to both hemorrhagic and thrombotic tendencies in this population. The aim of this study was to investigate the association between pretransplant procoagulants/anticoagulants and posttransplant bleeding and thrombosis among living donor liver transplant recipients.

The clinical course of cirrhosis: The importance of multistate models and competing risks analysis

Peter Jepsen, Hendrik Vilstrup, Per Kragh Andersen – 5 November 2014 – Multistate models are models of disease progression that, for a patient group, define multiple outcome events, each of which may affect the time to develop another outcome event. Multistate models are highly relevant for studies of patients with cirrhosis; both the classical perception of cirrhosis as either compensated or decompensated and the recent, more complex models of cirrhosis progression are multistate models.

Competition in liver transplantation: Helpful or harmful?

Reza F. Saidi, Moaven Razavi, A. Benedict Cosimi, Dicken S. C. Ko – 5 November 2014 – Improved outcomes of liver transplantation have led to increases in the numbers of US transplant centers and candidates on the list. The resultant and ever‐expanding organ shortage has created competition among centers, especially in regions with multiple liver transplant programs. Multiple reports now document that competition among the country's transplant centers has led to the listing of increasingly high‐risk patients and the utilization of more marginal liver allografts.

Estimation of hepatitis C virus infections resulting from vertical transmission in Egypt

Lenka Benova, Susanne F. Awad, F. DeWolfe Miller, Laith J. Abu‐Raddad – 4 November 2014 – Despite having the highest hepatitis C virus (HCV) prevalence in the world, the ongoing level of HCV incidence in Egypt and its drivers are poorly understood. Whereas HCV mother‐to‐child infection is a well‐established transmission route, there are no estimates of HCV infections resulting from vertical transmission for any country, including Egypt. The aim of this study was to estimate the absolute number of new HCV infections resulting from vertical transmission in Egypt.

Central nervous system complications after liver transplantation: Common but mostly transient phenomena

Martina Bernhardt, Henning Pflugrad, Annemarie Goldbecker, Hannelore Barg‐Hock, Wolfgang Knitsch, Jürgen Klempnauer, Christian P. Strassburg, Hartmut Hecker, Karin Weissenborn, Anita Blanka Tryc – 4 November 2014 – Although central nervous system complications (CNSCs) are common after orthotopic liver transplantation (OLT), standardized prospective studies are still lacking. This prospective study was aimed at determining the incidence of CNSCs, describing their clinical presentations, and establishing predicting factors.

Immediate extubation after pediatric liver transplantation: A single‐center experience

Nora M. Fullington, Ryan P. Cauley, Kristina M. Potanos, Laura O'Melia, David Zurakowski, Heung Bae Kim, Christian Seefelder, Khashayar Vakili – 4 November 2014 – The care of pediatric liver transplant recipients has traditionally included postoperative mechanical ventilation. In 2005, we started extubating children undergoing liver transplantation in the operating room according to standard criteria for extubation used for general surgery cases. We reviewed our single‐center experience to determine our rates of immediate extubation and practice since that time.

Estimation of hepatitis C virus infections resulting from vertical transmission in Egypt

Lenka Benova, Susanne F. Awad, F. DeWolfe Miller, Laith J. Abu‐Raddad – 4 November 2014 – Despite having the highest hepatitis C virus (HCV) prevalence in the world, the ongoing level of HCV incidence in Egypt and its drivers are poorly understood. Whereas HCV mother‐to‐child infection is a well‐established transmission route, there are no estimates of HCV infections resulting from vertical transmission for any country, including Egypt. The aim of this study was to estimate the absolute number of new HCV infections resulting from vertical transmission in Egypt.

Experience with molecular adsorbent recirculating system treatment in 20 children listed for high‐urgency liver transplantation

Willem S. Lexmond, Carin M. L. Van Dael, René Scheenstra, Joanne F. Goorhuis, Egbert Sieders, Henkjan J. Verkade, Patrick F. Van Rheenen, Martin Kömhoff – 4 November 2014 – For more than 10 years, children at our national center for pediatric liver transplantation (LT) have been treated with Molecular Adsorbent Recirculating System (MARS) liver dialysis as a bridging therapy to high‐urgency LT. Treatment was reserved for 20 patients with the highest degrees of hepatic encephalopathy (HE; median grade = 3.5).

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