Total tumor volume and alpha‐fetoprotein for selection of transplant candidates with hepatocellular carcinoma: A prospective validation

Christian Toso, Glenda Meeberg, Roberto Hernandez‐Alejandro, Jean‐François Dufour, Paul Marotta, Pietro Majno, Norman M. Kneteman – 17 March 2015 – The selection of liver transplantation (LT) candidates with hepatocellular carcinoma (HCC) is currently validated based on Milan criteria. The use of extended criteria has remained a matter of debate, mainly because of the absence of prospective validation. The present prospective study recruited patients according to the previously proposed total tumor volume (TTV; ≤115 cm3)/alpha‐fetoprotein (AFP; ≤400 ng/mL) score.

Combinations of biomarkers and Milan criteria for predicting hepatocellular carcinoma recurrence after liver transplantation

Roongruedee Chaiteerakij, Xiaodan Zhang, Benyam D. Addissie, Essa A. Mohamed, William S. Harmsen, Paul J. Theobald, Brian E. Peters, Joseph G. Balsanek, Melissa M. Ward, Nasra H. Giama, Catherine D. Moser, Abdul M. Oseini, Naoki Umeda, Sudhakar Venkatesh, Denise M. Harnois, Michael R. Charlton, Hiroyuki Yamada, Shinji Satomura, Alicia Algeciras‐Schimnich, Melissa R. Snyder, Terry M. Therneau, Lewis R. Roberts – 17 March 2015 – Growing evidence suggests that pretransplant alpha‐fetoprotein (AFP) predicts outcomes of hepatocellular carcinoma (HCC) patients treated with liver transplantation.

Fully laparoscopic left‐sided donor hepatectomy is safe and associated with shorter hospital stay and earlier return to work: A comparative study

Benjamin Samstein, Adam Griesemer, Daniel Cherqui, Tarek Mansour, Joseph Pisa, Anna Yegiants, Alyson N. Fox, James V. Guarrera, Tomoaki Kato, Karim J. Halazun, Jean Emond – 17 March 2015 – Living donor liver transplantation has failed to become a major means of transplantation in the United States, where <5% of the transplants are performed with living donors. At least 30% to 50% of the complications of donor hepatectomy appear to be related to abdominal wall trauma, including hernia, bowel obstruction, and chronic abdominal discomfort.

Oral ampicillin inhibits liver regeneration by breaking hepatic innate immune tolerance normally maintained by gut commensal bacteria

Xunyao Wu, Rui Sun, Yongyan Chen, Xiaodong Zheng, Li Bai, Zhexiong Lian, Haiming Wei, Zhigang Tian – 17 March 2015 – Commensal bacteria have been proposed to play a role in liver repair after partial (67%) hepatectomy. However, the underlying immune mechanisms remain elusive. Here, we show that liver regeneration was impaired in antibiotic (Atb) water‐treated mice and this impairment strongly correlated with commensal bacterial load. Among the various Atbs used in our cocktail, ampicillin‐sensitive commensal bacterial was associated with normal liver regeneration.

Nrf2, but not β‐catenin, mutation represents an early event in rat hepatocarcinogenesis

Patrizia Zavattari, Andrea Perra, Silvia Menegon, Marta Anna Kowalik, Annalisa Petrelli, Maria Maddalena Angioni, Antonia Follenzi, Luca Quagliata, Giovanna Maria Ledda‐Columbano, Luigi Terracciano, Silvia Giordano, Amedeo Columbano – 17 March 2015 – Hepatocellular carcinoma (HCC) develops through a multistage process, but the nature of the molecular changes associated with the different steps, the very early ones in particular, is largely unknown.

Decision support for organ offers in liver transplantation

Michael L. Volk, Nathan Goodrich, Jennifer C. Lai, Christopher Sonnenday, Kerby Shedden – 16 March 2015 – Organ offers in liver transplantation are high‐risk medical decisions with a low certainty of whether a better liver offer will come along before death. We hypothesized that decision support could improve the decision to accept or decline. With data from the Scientific Registry of Transplant Recipients, survival models were constructed for 42,857 waiting‐list patients and 28,653 posttransplant patients from 2002 to 2008.

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