Dual ablation of β‐ and γ‐catenin: Critical regulators of junctions and their functions
Heather Francis, Lindsey Kennedy, Gianfranco Alpini – 22 December 2017
Hepatocellular carcinoma due to a baffle obstruction after the mustard operation: A case report
Takeo Yoshihara, Ryotaro Sakamori, Kunimaro Furuta, Minoru Shigekawa, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Takayuki Yakushijin, Tomohide Tatsumi, Yasushi Sakata, Hidetoshi Eguchi, Yoshiki Sawa, Tetsuo Takehara – 22 December 2017
Liver‐specific deficiency of unc‐51 like kinase 1 and 2 protects mice from acetaminophen‐induced liver injury
Yu Sun, Terytty Yang Li, Lintao Song, Cixiong Zhang, Jingyi Li, Zhi‐Zhong Lin, Sheng‐Cai Lin, Shu‐Yong Lin – 22 December 2017 – unc‐51‐like autophagy activating kinase 1 and 2 (Ulk1/2) regulate autophagy initiation under various stress conditions. However, the physiological functions of these Ser/Thr kinases are not well characterized. Here, we show that mice with liver‐specific double knockout (LDKO) of Ulk1 and Ulk2 (Ulk1/2 LDKO) are viable, but exhibit overt hepatomegaly phenotype.
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Implications for liver transplantation
Zobair M. Younossi – 22 December 2017 – Nonalcoholic fatty liver disease (NAFLD), a common cause of chronic liver disease (CLD), has a global prevalence of 25%. Its progressive form, nonalcoholic steatohepatitis (NASH), is a leading indication for liver transplantation (LT) in the United States. As a result, specialty societies, including the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver, have developed guidance on the epidemiology, diagnosis, and treatment of NAFLD and NASH.
The case for normothermic machine perfusion in liver transplantation
Carlo D. L. Ceresa, David Nasralla, Constantin C. Coussios, Peter J. Friend – 22 December 2017 – In recent years, there has been growing interest in normothermic machine perfusion (NMP) as a preservation method in liver transplantation. In most countries, because of a donor organ shortage, an unacceptable number of patients die while awaiting transplantation. In an attempt to increase the number of donor organs available, transplant teams are implanting a greater number of high‐risk livers, including those from donation after circulatory death, older donors, and donors with steatosis.
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Implications for liver transplantation
Zobair M. Younossi – 22 December 2017 – Nonalcoholic fatty liver disease (NAFLD), a common cause of chronic liver disease (CLD), has a global prevalence of 25%. Its progressive form, nonalcoholic steatohepatitis (NASH), is a leading indication for liver transplantation (LT) in the United States. As a result, specialty societies, including the American Association for the Study of Liver Diseases (AASLD) and the European Association for the Study of the Liver, have developed guidance on the epidemiology, diagnosis, and treatment of NAFLD and NASH.
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Elliot B. Tapper, Anna S.‐F. Lok, Grace L. Su – 21 December 2017
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Hamish Innes, Andrew McAuley, David Goldberg, Sharon J. Hutchinson – 21 December 2017
Extreme large‐for‐size syndrome after adult liver transplantation: A model for predicting a potentially lethal complication
Matthew Jacob, Rehan Saif, Jayanth Reddy, Noushif Medappil, Sonal Asthana, Rajiv Lochan – 21 December 2017
Liver tissue engineering: From implantable tissue to whole organ engineering
Giuseppe Mazza, Walid Al‐Akkad, Krista Rombouts, Massimo Pinzani – 21 December 2017 – The term “liver tissue engineering” summarizes one of the ultimate goals of modern biotechnology: the possibility of reproducing in total or in part the functions of the liver in order to treat acute or chronic liver disorders and, ultimately, create a fully functional organ to be transplanted or used as an extracorporeal device.