Treatment Status of Hepatocellular Carcinoma Does Not Influence Rates of Sustained Virologic Response: An HCV‐TARGET Analysis

Kavita Radhakrishnan, Adrian M. Di Bisceglie, K. Rajender Reddy, Joseph K. Lim, Josh Levitsky, Mohamed A. Hassan, Jama M. Darling, Jordan J. Feld, Lucy Akushevich, Monika Vainorius, David R. Nelson, Michael W. Fried, Robert S. Brown, Norah A. Terrault – 7 August 2019 – Recent studies have suggested a negative impact of hepatocellular carcinoma (HCC) on sustained virologic response (SVR) to hepatitis C virus (HCV) direct acting antivirals (DAAs).

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Feng Zhou, Jianghua Zhou, Wenxin Wang, Xiao‐Jing Zhang, Yan‐Xiao Ji, Peng Zhang, Zhi‐Gang She, Lihua Zhu, Jingjing Cai, Hongliang Li – 7 August 2019

Liver X Receptor α–Induced Cannabinoid Receptor 2 Inhibits Ubiquitin‐Specific Peptidase 4 Through miR‐27b, Protecting Hepatocytes From TGF‐β

Hong Min Wu, Tae Hyun Kim, Ayoung Kim, Ja Hyun Koo, Min Sung Joo, Sang Geon Kim – 5 August 2019 – Liver X receptor‐alpha (LXRα) acts as a double‐edged sword in different biological situations. Given the elusive role of LXRα in hepatocyte viability, this study investigated whether LXRα protects hepatocytes from injurious stimuli and the underlying basis. LXRα activation prevented hepatocyte apoptosis from CCl4 challenges in mice.

Dual Programmed Death Receptor‐1 and Vascular Endothelial Growth Factor Receptor‐2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma

Kohei Shigeta, Meenal Datta, Tai Hato, Shuji Kitahara, Ivy X. Chen, Aya Matsui, Hiroto Kikuchi, Emilie Mamessier, Shuichi Aoki, Rakesh R. Ramjiawan, Hiroki Ochiai, Nabeel Bardeesy, Peigen Huang, Mark Cobbold, Andrew X. Zhu, Rakesh K. Jain, Dan G. Duda – 5 August 2019

Hepatology Highlights

Petra Hirsova, Harmeet Malhi, Nicholas Russo, Pir A. Shah, Hirsh Trivedi, Daryl T.Y. Lau, Joseph F. Pisa, Ashley Wu, Nicole Shen, Arun Jesudian, Zaid H. Tafesh, Brett E. Fortune, Moira Hilscher, Nidhi Jalan‐Sakrikar, Omar Mousa – 5 August 2019

Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease

Francesco De Chiara, Karen Louise Thomsen, Abeba Habtesion, Helen Jones, Nathan Davies, Jordi Gracia‐Sancho, Nicolò Manicardi, Andrew Hall, Fausto Andreola, Hannah L. Paish, Lee H. Reed, Abigail A. Watson, Jack Leslie, Fiona Oakley, Krista Rombouts, Rajeshwar Prosad Mookerjee, Jelena Mann, Rajiv Jalan – 5 August 2019

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