Liver Glycogen Phosphorylase Deficiency Leads to Profibrogenic Phenotype in a Murine Model of Glycogen Storage Disease Type VI

Lane H. Wilson, Jun‐Ho Cho, Ana Estrella, Joan A. Smyth, Rong Wu, Tayoot Chengsupanimit, Laurie M. Brown, David A. Weinstein, Young Mok Lee – 24 September 2019 – Mutations in the liver glycogen phosphorylase (Pygl) gene are associated with the diagnosis of glycogen storage disease type VI (GSD‐VI). To understand the pathogenesis of GSD‐VI, we generated a mouse model with Pygl deficiency (Pygl−/−). Pygl−/− mice exhibit hepatomegaly, excessive hepatic glycogen accumulation, and low hepatic free glucose along with lower fasting blood glucose levels and elevated blood ketone bodies.

RPB5‐Mediating Protein Promotes Cholangiocarcinoma Tumorigenesis and Drug Resistance by Competing With NRF2 for KEAP1 Binding

Zheng‐Hua Wan, Tian‐Yi Jiang, Yuan‐Yuan Shi, Yu‐Fei Pan, Yun‐Kai Lin, Yun‐Han Ma, Chun Yang, Xiao‐Fan Feng, Li‐Feng Huang, Xiao‐Ni Kong, Zhi‐Wen Ding, Ye‐Xiong Tan, Li‐Wei Dong, Hong‐Yang Wang – 21 September 2019

The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice

Xue Feng, Tiantian Lu, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng, Wei Tian, Lei Zhang – 20 September 2019

Intraoperative Events in Liver Transplantation Using Donation After Circulatory Death Donors

Ryan M. Chadha, Kristopher P. Croome, Stephen Aniskevich, Sher‐Lu Pai, Justin Nguyen, Justin Burns, Dana Perry, C. Burcin Taner – 20 September 2019 – Liver grafts from donation after circulatory death (DCD) are a source of organs to decrease wait‐list mortality. While there have been lower rates of graft loss, there are concerns of an increased incidence of intraoperative events in recipients of DCD grafts. We aim to look at the incidence of intraoperative events between recipients of livers from DCD and donation after brain death (DBD) donors.

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