Thyroid Hormone Signaling and the Liver

Megan J. Ritter, Izuki Amano, Anthony N. Hollenberg – 28 April 2020 – Thyroid hormone (TH) plays a critical role in maintaining metabolic homeostasis throughout life. It is well known that the liver and thyroid are intimately linked, with TH playing important roles in de novo lipogenesis, beta‐oxidation (fatty acid oxidation), cholesterol metabolism, and carbohydrate metabolism. Indeed, patients with hypothyroidism have abnormal lipid panels with higher levels of low‐density lipoprotein levels, triglycerides (triacylglycerol; TAG), and apolipoprotein B levels.

Growth Hormone Stops Excessive Inflammation After Partial Hepatectomy, Allowing Liver Regeneration and Survival Through Induction of H2‐Bl/HLA‐G

Mayumi Ishikawa, Andrew J. Brooks, Manuel A. Fernández‐Rojo, Johan Medina, Yash Chhabra, Shiro Minami, Kathryn A. Tunny, Robert G. Parton, Julian P. Vivian, Jamie Rossjohn, Viral Chikani, Grant A. Ramm, Ken K.Y. Ho, Michael J. Waters – 27 April 2020

Breath Metabolomics Provides an Accurate and Noninvasive Approach for Screening Cirrhosis, Primary, and Secondary Liver Tumors

Galen Miller‐Atkins, Lou‐Anne Acevedo‐Moreno, David Grove, Raed A. Dweik, Adriano R. Tonelli, J. Mark Brown, Daniela S. Allende, Federico Aucejo, Daniel M. Rotroff – 26 April 2020 – Hepatocellular carcinoma (HCC) and secondary liver tumors, such as colorectal cancer liver metastases are significant contributors to the overall burden of cancer‐related morality. Current biomarkers, such as alpha‐fetoprotein (AFP) for HCC, result in too many false negatives, necessitating noninvasive approaches with improved sensitivity.

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Reinout L.P. Roscam Abbing, Folkert Kuipers, Coen C. Paulusma, Henkjan J. Verkade, Albert K. Groen, Ronald P.J. Oude Elferink, Stan F.J. Graaf – 25 April 2020

Functional Comparison of Interferon‐α Subtypes Reveals Potent Hepatitis B Virus Suppression by a Concerted Action of Interferon‐α and Interferon‐γ Signaling

Jieliang Chen, Yaming Li, Fritz Lai, Yang Wang, Kathrin Sutter, Ulf Dittmer, Jianyu Ye, Wenjing Zai, Min Liu, Fang Shen, Min Wu, Kongying Hu, Baocun Li, Mengji Lu, Xiaonan Zhang, Jiming Zhang, Jianhua Li, Qingfeng Chen, Zhenghong Yuan – 25 April 2020

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