Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity

Haisheng Yu, Mengqi Li, Rui He, Peining Fang, Qiming Wang, Yu Yi, Fubing Wang, Li Zhou, Yi Zhang, Aidong Chen, Nanfang Peng, Dan Liu, Mirko Trilling, Ruth Broering, Erik A.C. Wiemer, Mengji Lu, Ying Zhu, Shi Liu – 23 November 2019

Hyperoxidized Albumin Modulates Platelets and Promotes Inflammation Through CD36 Receptor in Severe Alcoholic Hepatitis

Adil Bhat, Sukanta Das, Gaurav Yadav, Sudrishti Chaudhary, Ashish Vyas, Mojahidul Islam, Abhishak C. Gupta, Meenu Bajpai, Rakhi Maiwall, Jaswinder Singh Maras, Shiv K. Sarin – 23 November 2019 – Hyperoxidized albumin promotes inflammation and modulates several immune cells in severe alcoholic hepatitis (SAH). Platelets mediate inflammation by interacting with immune cells, endothelium, and other cells. The role of hyperoxidized albumin in platelet activation and alteration of platelet phenotype/functions is not known.

Transplant Outcomes of Donation After Circulatory Death Livers Recovered With Versus Without Premortem Heparin Administration

J. Reinier F. Narvaez, Jing Nie, Katia Noyes, Liise K. Kayler – 22 November 2019 – Premortem heparin administration during donation after circulatory death (DCD) organ recovery is thought to optimize liver perfusion. However, premortem heparinization is not universally practiced in the United States and limited data exist regarding its utility.

Hepatocyte‐Specific Magnetic Resonance Imaging–Based Assessment of Indeterminate Hepatic Nodules in the Liver Transplant Evaluation of Patients With Cirrhosis

Ha Il Kim, Jong Keon Jang, Jihye Lim, Seheon Chang, Jihyun An, Hyo Jeong Kang, Gi‐Won Song, Sung‐Gyu Lee, So Yeon Kim, Ju Hyun Shim – 22 November 2019 – We aimed to determine the identities in explants of indeterminate hepatic nodules (IDNs) that had been scanned by dynamic magnetic resonance imaging (MRI) to establish clinicoradiological parameters predicting which IDNs were hepatocellular carcinomas (HCCs). This study included 88 patients with cirrhosis who underwent gadoxetic acid–enhanced MRI in pre–liver transplantation (LT) workup followed within 90 days by primary LT.

Autologous Adipose Tissue–Derived Mesenchymal Stem Cells Introduced by Biliary Stents or Local Immersion in Porcine Bile Duct Anastomoses

Yi Zhang, Ayushman Sharma, Dong Jin Joo, Erek Nelson, Anan AbuRmilah, Bruce P. Amiot, Christen J. Boyer, Jonathan S. Alexander, Nidhi Jalan‐Sakrikar, John Martin, Roger Moreira, Shiraj A. Chowdhury, Michele Smart, Allan B. Dietz, Scott L. Nyberg, Julie K. Heimbach, Robert C. Huebert – 19 November 2019 – Biliary complications (strictures and leaks) represent major limitations in living donor liver transplantation. Mesenchymal stem cells (MSCs) are a promising modality to prevent biliary complications because of immunosuppressive and angiogenic properties.

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