Major Vault Protein Promotes Hepatocellular Carcinoma Through Targeting Interferon Regulatory Factor 2 and Decreasing p53 Activity

Haisheng Yu, Mengqi Li, Rui He, Peining Fang, Qiming Wang, Yu Yi, Fubing Wang, Li Zhou, Yi Zhang, Aidong Chen, Nanfang Peng, Dan Liu, Mirko Trilling, Ruth Broering, Erik A.C. Wiemer, Mengji Lu, Ying Zhu, Shi Liu – 23 November 2019

Hyperoxidized Albumin Modulates Platelets and Promotes Inflammation Through CD36 Receptor in Severe Alcoholic Hepatitis

Adil Bhat, Sukanta Das, Gaurav Yadav, Sudrishti Chaudhary, Ashish Vyas, Mojahidul Islam, Abhishak C. Gupta, Meenu Bajpai, Rakhi Maiwall, Jaswinder Singh Maras, Shiv K. Sarin – 23 November 2019 – Hyperoxidized albumin promotes inflammation and modulates several immune cells in severe alcoholic hepatitis (SAH). Platelets mediate inflammation by interacting with immune cells, endothelium, and other cells. The role of hyperoxidized albumin in platelet activation and alteration of platelet phenotype/functions is not known.

Transplant Outcomes of Donation After Circulatory Death Livers Recovered With Versus Without Premortem Heparin Administration

J. Reinier F. Narvaez, Jing Nie, Katia Noyes, Liise K. Kayler – 22 November 2019 – Premortem heparin administration during donation after circulatory death (DCD) organ recovery is thought to optimize liver perfusion. However, premortem heparinization is not universally practiced in the United States and limited data exist regarding its utility.

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