Focal Adhesion Kinase Promotes Hepatic Stellate Cell Activation by Regulating Plasma Membrane Localization of TGFβ Receptor 2

Yunru Chen, Qing Li, Kangsheng Tu, Yuanguo Wang, Xianghu Wang, Dandan Liu, Chen Chen, Donglian Liu, Rendong Yang, Wei Qiu, Ningling Kang – 20 December 2019 – Transforming growth factor β (TGFβ) induces hepatic stellate cell (HSC) differentiation into tumor‐promoting myofibroblast, although underlying mechanism remains incompletely understood. Focal adhesion kinase (FAK) is activated in response to TGFβ stimulation, so it transmits TGFβ stimulus to extracellular signal‐regulated kinase and P38 mitogen‐activated protein kinase signaling.

Highly Sensitive Circulating MicroRNA Panel for Accurate Detection of Hepatocellular Carcinoma in Patients With Liver Disease

Yusuke Yamamoto, Shunsuke Kondo, Juntaro Matsuzaki, Minoru Esaki, Takuji Okusaka, Kazuaki Shimada, Yoshiki Murakami, Masaru Enomoto, Akihiro Tamori, Ken Kato, Yoshiaki Aoki, Satoko Takizawa, Hiromi Sakamoto, Shumpei Niida, Fumitaka Takeshita, Takahiro Ochiya – 19 December 2019 – Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer deaths worldwide. The high mortality rate in HCC is largely due to the difficulty of early detection.

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