Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice

Anita M. Hoek, Elsbet J. Pieterman, José W. Hoorn, Marta Iruarrizaga‐Lejarreta, Cristina Alonso, Lars Verschuren, Tore Skjæret, Hans M.G. Princen, David A. Fraser – 24 December 2019 – Icosabutate is a structurally engineered eicosapentaenoic acid derivative under development for nonalcoholic steatohepatitis (NASH).

TGF‐β Signaling Plays a Pivotal Role During Developmental Biliary Atresia in Sea Lamprey (Petromyzon marinus)

Yu‐Wen Chung‐Davidson, Jianfeng Ren, Chu‐Yin Yeh, Ugo Bussy, Belinda Huerta, Peter Joseph Davidson, Steven Whyard, Weiming Li – 24 December 2019 – Biliary atresia (BA) is a rare neonatal disease with unknown causes. Approximately 10% of BA cases develop in utero with other congenital defects that span a large spectrum of disease variations, including degeneration of the gall bladder and bile duct as well as malformation of the liver, intestines, and kidneys.

Clinical Outcomes of Portosystemic Shunts on the Outcome of Liver Transplantation

Eduardo A. Rodriguez, Rachel Perez, Nan Zhang, Elisabeth S. Lim, Christopher Miller, Michael A. Schwartz, Aidan J. McGirr, Ananth Srinivasan, Winston Hewitt, Alvin C. Silva, Jorge Rakela, Hugo E. Vargas – 24 December 2019 – Spontaneous portosystemic shunts (SPSSs) have been associated with worse clinical outcomes in the pre–liver transplantation (LT) setting, but little is known about their post‐LT impacts. Our aim was to compare LT candidates with and without SPSSs and assess the impact of SPSSs on patient mortality and graft survival in the post‐LT setting.

Living Donor Liver Transplantation When Deceased Donor Is Not Possible or Timely: Case Examples and Ethical Perspectives

Josh Levitsky, Elisa J. Gordon – 24 December 2019 – This article analyzes the ethical soundness of living donor liver transplantation (LDLT) in situations where the transplant team does not consider deceased donor liver transplantation (DDLT) a clinical or timely option. Given that patients with end‐stage liver disease have a high risk of death without DDLT, the option of LDLT becomes compelling and may save lives.

Cardiac and Liver Disease in Children: Implications for Management Before and After Liver Transplantation

Nicola D. Ruth, Nigel E. Drury, James Bennett, Deirdre A. Kelly – 24 December 2019 – There is close interaction between the functions of the liver and heart affecting the presentation, diagnosis, and outcome of acute and chronic cardiac and liver disease. Conditions affecting both organ systems should be considered when proposing transplantation because the interaction between cardiac disease and liver disease has implications for diagnosis, management, selection for transplantation, and, ultimately, for longterm outcomes after liver transplantation (LT).

Posttransplant Complications Predict Alcohol Relapse in Liver Transplant Recipients

Toshihiro Kitajima, Shunji Nagai, Antu Segal, Michelle Magee, Shaundra Blackburn, Donna Ellithorpe, Siri Yeddula, Yusuf Qadeer, Atsushi Yoshida, Dilip Moonka, Kimberly Brown, Marwan S. Abouljoud – 24 December 2019 – Alcohol relapse after liver transplantation (LT) in patients with alcohol‐related liver disease (ALD) is a major challenge. Although its association with pretransplant psychosocial factors was extensively studied, the impacts of posttransplant courses on alcohol relapse have not been well investigated.

Endogenous Interleukin 18 Suppresses Liver Regeneration After Hepatectomy in Mice

Tao Ma, Yibo Zhang, Mengyi Lao, Wen Chen, Qida Hu, Xiao Zhi, Zhiliang Chen, Xueli Bai, Xiaowei Dang, Tingbo Liang – 24 December 2019 – The comprehensive role of interleukin (IL) 18 during liver regeneration is barely studied. Our aim is to evaluate the role of IL18 in liver regeneration after partial hepatectomy (PH) in mice. The expression profile of IL18 in the liver and the gut after 70% PH was measured. Liver samples after 70% and 85% PH from IL18 knockout (IL18−/−) mice and wild type (WT) mice were collected for comparison of liver regeneration.

Subscribe to