FEASIBILITY AND RESULTS OF AN INPATIENT TELEHEPATOLOGY CONSULT SERVICE IN AN INTEGRATED HEALTH SYSTEM

<div><p><b>Background: </b>Providers at community hospitals often seek to transfer hospitalized patients with advanced liver disease to tertiary/quaternary care hospitals for further management due to lack of expertise in caring for these patients. However, it is possible to co-manage such patients at local hospitals by providing virtual consultation by tertiary care hepatologists via inpatient telehepatology (INP-TH) consultation.

SERUM Z POLYMER LEVELS AND FACTORS AFFECTING INCREASED LIVER FIBROSIS ARE ASSOCIATED WITH FUTURE SEVERE LIVER DISEASE OUTCOMES IN A PROSPECTIVE COHORT OF ADULTS WITH ALPHA-1-ANTITRYPSIN DEFICIENCY .

<div><p><strong>Background</strong>: <span data-contrast="none" xml:lang="EN-US" lang="EN-US" class="TextRun SCXW199784672 BCX0"><span class="NormalTextRun SCXW199784672 BCX0" data-ccp-charstyle="x_x_normaltextrun">Outcomes of adults with ZZ alpha-1-antitrypsin deficiency (AATD) liver disease is variable and unpredictable. There is a lack of prospective data, including on the utility of liver biopsy.

FIBROSIS IMPROVEMENT WITH PEGOZAFERMIN TREATMENT IN MASH PATIENTS WITH F4 FIBROSIS: ANALYSIS FROM A 24-WEEK RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PHASE 2 TRIAL (ENLIVEN)

<div><p><b>Background:</p> </b><p>Metabolic dysfunction-associated steatohepatitis (MASH) patients who have developed stage F4 fibrosis (cirrhosis) are at risk of hepatic decompensation, hepatocellular carcinoma, liver transplant, cardiovascular events, liver and all-cause mortality. There are currently no approved therapies for non-cirrhotic or cirrhotic MASH.</p>

MORTALITY, HEPATIC DECOMPENSATION, AND CARDIOVASCULAR OUTCOMES IN LEAN VS. NON-LEAN MASH CIRRHOSIS: A VETERANS AFFAIRS COHORT STUDY

<div><p><b>Background: </b>Studies on incident liver and cardiovascular outcomes in lean (body mass index: BMI &lt;25 kg/m<sup>2</sup>, or &lt;23 kg/m<sup>2</sup> for Asians) vs. non-lean individuals with metabolic dysfunction-associated steatohepatitis (MASH) have reported mixed results. We aimed to compare incident clinical outcomes and mortality between lean and non-lean individuals with compensated MASH cirrhosis in a large national cohort.</p>

MULTI-ANCESTRY WHOLE GENOME SEQUENCING (WGS) AND META-ANALYSIS TO IDENTIFY LOCI ASSOCIATED WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD)

<div><p><b>Background: </b>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver disease in the US. Notably, disease prevalence differs greatly by race/ethnicity, with the highest prevalence in those of Hispanic and Asian ancestry, and the lowest prevalence in those of African ancestry. To date, studies have identified common variants associated with MASLD in predominantly European or American populations.

HEALTHCARE ACCESS THROUGH FACILITATED TELEMEDICINE FOR UNDERSERVED POPULATIONS: A STEPPED WEDGE CLUSTER RANDOMIZED CONTROLLED TRIAL OF HEPATITIS C VIRUS TREATMENT AMONG PERSONS WITH OPIOID USE DISORDER

<div><p><b>Background: </b>Telemedicine removes geographic and temporal obstacles to healthcare access. Few randomized trials have evaluated telemedicine effectiveness for underserved populations. We compared sustained virological response (SVR12) rates for hepatitis C virus (HCV) infection among persons with opioid use disorder through facilitated telemedicine (FTM) versus offsite liver specialist referral (usual care or UC).</p>

TRIPLE HORMONE RECEPTOR AGONIST RETATRUTIDE RESOLVES STEATOSIS IN >85 % OF SUBJECTS WITH MASLD AND OBESITY IN ASSOCIATION WITH IMPROVED METABOLIC HEALTH

<div><p><b>Background: </b>Retatrutide (RETA; LY3437943) is a novel triple agonist of the GIP, GLP-1 and glucagon receptors under investigation for obesity treatment. A 48-week phase 2 obesity study demonstrated weight loss of −22.8% and −24.2% with RETA 8 and 12 mg. We report effects of RETA on liver fat (LF) and correlations with metabolic measures in subjects with MASLD included in this trial.</p>

A RHESUS MACAQUE MODEL OF HIV/HBV CO-INFECTION

<div><p><b>Background: </b>HBV and HIV are both major global health concerns as HBV infects 296 million people while HIV infects 38 million individuals worldwide.<sup> </sup>HIV/HBV co-infection is common due to similar routes of transmission, with an estimated 10% of HIV-infected individuals also infected with HBV. HIV/HBV co-infected individuals progress to chronic HBV infection more frequently and exhibit reduced HBV-specific T cell responses, with a higher probability of extensive liver fibrosis and hepatocellular carcinomas.

LINKAGE OF LIVER STIFFNESS WITH COGNITIVE PERFORMANCE ACROSS THE SPECTRUM OF CHRONIC LIVER DISEASE AND IMPACT ON QOL: A MULTI-NATIONAL STUDY

<div><p><strong>Background</strong>: Quality of life and symptom management are important for patients with chronic liver disease (CLD), which can precede cirrhosis development. CLD patients with/without cirrhosis have mood disorders which affect cognition. Cognitive impairment is testing using simple (Animal naming, ANT) or more complicated [Stroop and Psychometric hepatic encephalopathy score (PHES)] but their impact on QOL across the spectrum of CLD is unclear.

EXTRACELLULAR MATRIX PROTEIN 1 ATTENUATES HEPATIC FIBROSIS BY INHIBITING PROTEASE-MEDIATED LATENT TGF-β1 ACTIVATION

<div><p><b>Background: </b>ECM1 depletion results in excessive latent TGF-β1 activation and lethal liver fibrosis in mice. In patients suffering from chronic liver diseases, ECM1 expression gradually decreases with increasing severity of fibrosis. We investigated the underlying mechanisms of how ECM1 contributes to tissue homeostasis in healthy livers and what changes occur during CLD progression.</p>

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