<div><p><b>Background:</p> </b><p>Cirrhosis now has the 10th highest mortality rate worldwide. Most cirrhosis deaths are caused by the emergence of clinical decompensation, and 4%–12% of those who have the disease, experience at least one episode of decompensation per year<strong>.</strong> These patients are highly susceptible to infections due to increased systemic inflammation leading to kidney failure and death.

<div><p><b>Background:</p> </b><p>Continuous renal replacement therapy (CRRT) is the preferred mode of dialysis in critically ill hemodynamically unstable patients and in addition removes the inflammatory cytokines that accumulate in sepsis. Sustained low-efficiency dialysis (SLED) is a hybrid modality of intermittent dialysis with the advantage of metabolic control, hemodynamic stability, at a reduced cost.

<div><p><strong><span><b>Background:</span> </b></strong><span> Circulating tumor DNA (ctDNA) is a promising non-invasive biomarker in cancer management. We aimed to assess the dynamic evolution of ctDNA in patients with hepatocellular carcinoma (HCC).</span></p>

<div><p><strong>Background</strong>:</p>

<div><p><b>Background: </b>Hepatic cholesterol accumulation and hypercholesterolemia are considered as the risk factors of hepatocellular carcinoma (HCC).<strong> </strong>However,<strong> </strong>the therapeutic effects of cholesterol lowering drugs for the treatment of HCC are controversial, indicating that the relationship between cholesterol metabolism and HCC is more complex than anticipated.</p>

<div><p><b>Background: </b>Hepatitis B surface Antigen (HBsAg) loss occurs in a minor fraction of patients with Chronic Hepatitis B (CHB) under interferon therapy. Identifying the host factors critical for CHB cure can help recognize those who would benefit from interferon therapy.</p>

<div><p><strong><b>Background:</strong> </b>The liver is a tolerising organ, to prevent continuous immune activation following the portal influx of antigens from the gut. Regulatory T cells (Treg) dampen inflammation and are important to prevent liver injury. We discovered that hepatocytes engulf and delete live Treg cells by <em>enclysis</em>, which was distinct from known cell-in-cell structure processes and thus can be targeted specifically (PMID: 31693899).

<div><p><strong><b>Background:</strong> </b>The mechanisms of alcoholic hepatitis (AH) are complex and involve the cross talk between organ systems. MiR150, one of the most abundant microRNAs in immune cells, has been implicated in various liver diseases, but its role in AH pathogenesis remains unclear. We aimed to determine the role of the miR150-mediated immune cells-liver axis in AH pathogenesis.</p>

<div><p><b>Background: </b>An outpatient prehabilitation strategy is feasible and effective in improving frailty in liver transplant (LT) candidates. We previously showed that attendance to physical therapy (PT) sessions results in a significant reduction in mortality, but were unable identify the frailty change threshold that yields such benefit.

<div><p><b>Background</b><span style="font-weight: 400;">:</span></p>