<div><p><strong>Background</strong>: The ongoing overdose crisis has led to an increase in transplantation of organs from HCV-infected donors (D+) to uninfected recipients (R-). We previously showed that an ultra-short course (1 day pre and 7 days post) of glecaprevir/pibrentasvir (G/P) combined with ezetimibe (E) prevented chronic infection in non-liver solid organ recipients.

<div><p><b>Background: </b>Non-selective-beta-blockers (NSBB) are main stay of therapy in portal hypertension management. Apart from direct portal pressure reduction, NSBB’s modulate inflammatory cascade, which could be beneficial in patients with acute decompensation (AD). We therefore aimed to evaluate effect of NSBB on 28-day mortality and markers of systemic inflammation in a propensity score matched (PSM) cohort of AD patients requiring intensive care unit(ICU) admission.</p>

<div><p><b>Background: </b>The liver has a remarkable regenerative capacity. Nevertheless, under chronic liver-damaging conditions, this capacity becomes exhausted, allowing the accumulation of fibrotic tissue and leading to end-stage liver disease. Enhancing the endogenous regenerative capacity by targeting regeneration breaks is a novel therapeutic approach. We set up an in vivo functional genetic screen to identify such regeneration breaks. Integrin Alpha FG-GAP Repeat Containing 1 (ITFG1) was one of the top hits.

<div><p><b>Background:<span> </b>Pollution from plastics is an increasing health threat. Microplastics are small plastic pieces, which are formed by direct synthesis for industrial or consumer applications as well as by environmental plastic degradation. As plastic degradation is increased by UV light and “weathering”, global warming has increased environmental microplastics.

<div><p><b>Background:</p> </b><p><em>PNPLA3</em> rs738409 polymorphism, obesity, and type 2 diabetes mellitus (T2DM) are strongly associated with non-alcoholic fatty liver disease (NAFLD) and its severity in children. Whether <em>PNPLA3</em> rs738409-related predisposition to NAFLD severity is influenced by obesity and T2DM in children with NAFLD is not known.

<div><p><b>Background: </b>Statins may very rarely cause drug induced liver injury (DILI) but its pathogenesis is not well understood. Genetic factors may play a role in the pathogenesis of liver injury due to selected agents. In this study, we investigated genetic factors associated with statin DILI through a genome wide association study (GWAS).</p>

<div><p><b>Background:</p> </b><p>Newborn Screening (NBS) is successful in identifying infants with fatal but treatable disorders enabling early intervention with favorable outcomes. Unfortunately, many congenital disorders in particular Wilson disease do not feature specific metabolic biomarkers nor analytical methods suitable for NBS even where highly effective preemptive treatments are available.

<div><p><b>Background:</p> </b><p>Statins reduce the risk of hepatic fibrosis in patients with chronic liver diseases. Since age, sex, and menopausal status modulate NAFLD pathogenesis and fibrosis risk, the effects of statins on hepatic fibrosis may vary by age and sex. We aimed to assess age-/sex-disparities in the association between statin use and the incidence of cirrhosis in patients with NAFLD.</p>

<div><p><b>Background:</p> </b><p>Alcohol related harms to adolescents and young adults (AYAs) are on the rise and a priority group for identification and treatment to prevent progression of alcohol-associated liver disease (ALD). Females are at higher risk of developing ALD compared to males secondary to biologic and social-cultural factors. However, whether this sex difference persists after an episode of acute alcoholic hepatitis (AH) is unknown.

<div><p><strong><b>Background:</strong> </b><strong> </strong>Emergency admissions related to chronic liver failure (CLF) are common, expensive and associated with frequent readmission. There are no multicenter randomized controlled trials (RCT) investigating models to reduce liver-related emergency admissions (LREA).