IDENTIFICATION OF ANTI-FIBROTIC microRNAs ENRICHED IN EXTRACELLULAR VESICLES DERIVED FROM BONE MARROW MESENCHYMAL STEM CELLS IN PATIENTS WITH DECOMPENSATED LIVER CIRRHOSIS.
<div><p><b>Background: </b>We have been developing a liver regeneration therapy for decompensated liver cirrhosis (DLC) using cultured autologous bone marrow mesenchymal stem cells (BMSCs). Currently, we are conducting a clinical trial called "Self-contained liver cirrhosis regeneration therapy (jRCT2063200014)". In our clinical trial, hepatic arterial infusion of cultured autologous BMSCs has ameliorated liver function and fibrosis in patients with DLC. However, the mechanism of anti-fibrotic action of BMSCs remain to be fully determined.