STAT3 SIGNALING MEDIATES FXR AGONIST PROTECTION IN ACUTE CHOLANGIOPATHY MOUSE MODEL
<div><p><b>Background:</p> </b><p>Primary sclerosing cholangitis (PSC),<span> </span>a chronic cholangiopathy, results in cholestasis, inflammation, and stricturing of intrahepatic and extrahepatic bile ducts. Recently, we have shown that the transcription factor STAT3 mediated, in part, the protective role of the FXR agonist, GW4064, in parenteral nutrition (PN)-associated cholestasis <em>(Ghosh et al., Hep comm 2023)</em>.