STAT3 SIGNALING MEDIATES FXR AGONIST PROTECTION IN ACUTE CHOLANGIOPATHY MOUSE MODEL

<div><p><b>Background:</p> </b><p>Primary sclerosing cholangitis (PSC),<span> </span>a chronic cholangiopathy, results in cholestasis, inflammation, and stricturing of intrahepatic and extrahepatic bile ducts. Recently, we have shown that the transcription factor STAT3 mediated, in part, the protective role of the FXR agonist, GW4064, in parenteral nutrition (PN)-associated cholestasis <em>(Ghosh et al., Hep comm 2023)</em>.

IMPROVED MEAN ARTERIAL PRESSURE FROM BASELINE TO THE END OF TREATMENT WITH TERLIPRESSIN IS ASSOCIATED WITH HEPATORENAL SYNDROME REVERSAL: A POOLED ANALYSIS OF 3 PHASE III STUDIES

<div><p><b>Background: </b>Hepatorenal syndrome type 1 (HRS-1) is a rapidly progressive form of renal failure associated with high mortality in patients (pts) with decompensated cirrhosis and ascites. The FDA-approved vasopressin analogue, terlipressin (terli), improves renal function in pts with HRS-1 by reducing portal hypertension and increasing effective arterial volume and mean arterial pressure (MAP)—a marker of the hemodynamic response to treatment.

ANONYMOUS LIVING LIVER DONATION IMPROVES ACCESS FOR MEDICALLY UNDERSERVED CHILDREN IN NEED OF LIVER TRANSPLANTATION: THE CANADIAN EXPERIENCE

<div><p><strong><b>Background:</strong> </b><span> </span><span> </span>Since our first pediatric anonymous non-directed live donor liver transplant (Anon-LDLT) performed in April 2005, 62 children have undergone live donor liver transplant (LDLT) with an anonymous non-directed graft. Anon-LDLT organs being allocated as per our deceased donor liver transplant wait list.

IMMUNE SYSTEM IN THE LIVER OF POST-TRANSPLANT ALLOIMMUNE HEPATITIS AND AUTOIMMUNE HEPATITIS PATIENTS TIPPED IN FAVOR OF NON-SUPPRESSIVE MECHANISMS.

<div><p><b>Background:</p> </b><p style="font-weight: 400;">Peripheral blood (PB) regulatory T cells (Tregs) in post-transplant alloimmune hepatitis (DAIH) &amp; autoimmune hepatitis (AIH) have poor regulatory function, however little is known about intrahepatic (IH) Tregs in both diseases.

LIPID INDUCED ENDOTHELIAL INTERCELLULAR ADHESION MOLECULE 1 (ICAM1) PROMOTES METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS

<div><p><b>Background: </b>During metabolic dysfunction-associated steatohepatitis (MASH), liver sinusoidal endothelial cells (LSECs) acquire a pro-inflammatory phenotype characterized by increased adhesion molecules expression and myeloid cells-associated liver inflammation culminating in disease progression. However, the exact molecular mediators of this phenomenon are unclear.

PATIENTS WITH ACUTE ON CHRONIC LIVER FAILURE ARE AT HIGHER RISK OF PROCEDURAL-RELATED BLEEDING

<div><p><b>Background: </b>Patients with decompensated cirrhosis are frequently hospitalized and often undergo multiple invasive procedures. We aimed to define the incidence of procedural-related bleeding in patients with acute on chronic liver failure (ACLF) and to compare it with that of patients without ACLF.</p>

THE LIVER TOOLKIT – AN INNOVATIVE INFORMATION TECHONOLOGY SOLUTION TO SCREEN PATIENTS IN GENERAL PRACTICE FOR UNDIAGNOSED CIRRHOSIS

<div><p><b>Background: </b>Detecting patients with undiagnosed chronic liver disease is a public health challenge. Patients with advanced fibrosis or compensated cirrhosis have much better outcomes than those with decompensated disease and may be eligible for interventions to prevent disease progression</p>

TENOFOVIR VERSUS ENTECAVIR IN PREVENTING HCC AND DEATH: ANSWER FROM A LARGE INTEGRATED HEALTH PLAN POPULATION

<div><p><b>Background:<span> </b>Chronic hepatitis B (CHB) suppressive therapy with tenofovir disoproxil (TDF) or entecavir (ETV) has been shown to reduce the risk of hepatocellular carcinoma (HCC) and mortality. However, controversy exists regarding if one treatment is better than the other.</span></p>

EFFICACY OF VITAMIN C ON AKI OUTCOMES IN CRITICALLY ILL PATIENTS WITH CIRRHOSIS AND MULTIDRUG-RESISTANT BACTERIAL INFECTIONS- A RANDOMIZED CONTROLLED TRIAL [NCT04494451

<div><p><b>Background:</p> </b><p><strong> </strong>Infections with multidrug-resistant organisms (MDR) are a common cause of organ failures and increased fatality in patients with cirrhosis. Sepsis is associated with increased oxidative stress with widespread endothelial, cellular injury and acute deficiency of vitamin C. Polymyxins used for <span>MDR infections have increased incidence of nephrotoxicity.

UNVEILING THE TOTAL BURDEN OF LIVER CANCER IN LOW SOCIO-DEMOGRAPHIC INDEX COUNTRIES FROM 2010-2019: EPIDEMIOLOGICAL TRENDS, ETIOLOGY, AND GENDER SPECIFIC PATTERNS

<div><p><b>Background: </b>Liver cancer poses a significant health challenge worldwide, but its burden in low Socio-Demographic Index (SDI) countries remains understudied. These countries face unique obstacles, including limited healthcare resources, inadequate screening programs, and a higher prevalence of risk factors like hepatitis B and C. Liver cancer has become a pressing public health issue, impacting individuals, communities, and healthcare systems in low SDI countries.

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