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Jasmohan S. Bajaj, Guadalupe Garcia‐Tsao, Patrick S. Kamath, Jacqueline G. O’Leary, K. Rajender Reddy, Florence Wong – 9 June 2021
Obeticholic Acid Decreases Intestinal Content of Enterococcus in Rats With Cirrhosis and Ascites
Kathleen Yan, Adelina Hung, Caitlin Parmer, Hui Yang, Dhanpat Jain, Bentley Lim, Andrew L. Goodman, Guadalupe Garcia‐Tsao – 9 June 2021 – The intestinal microbiome and bacterial translocation (BT), the passage of microorganisms from the gut lumen to mesenteric lymph nodes and other extra‐intestinal sites, are main mechanisms implicated in liver injury and further decompensation in patients with cirrhosis. We hypothesized that obeticholic acid (OCA), a semisynthetic bile acid, would change the microbiome composition and reduce bacterial translocation in experimental cirrhosis.
The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol‐Associated Hepatitis
Jessica A. Musto, Jens Eickhoff, Meritxell Ventura‐Cots, Juan G. Abraldes, Francisco Bosques‐Padilla, Elizabeth C. Verna, Robert S. Brown, Victor Vargas, Jose Altamirano, Juan Caballería, Debbie Shawcross, Alexandre Louvet, Philippe Mathurin, Guadalupe Garcia‐Tsao, Bernd Schnabl, Ramon Bataller, Michael R. Lucey – 9 June 2021 – The 10‐item Alcohol Use Disorders Identification Test (AUDIT‐10) and its shorter form, AUDIT‐Consumption (AUDIT‐C), are questionnaires used to characterize severity of drinking.
Immune Activation Induces Telomeric DNA Damage and Promotes Short‐Lived Effector T Cell Differentiation in Chronic HCV Infection
Lam Nhat Nguyen, Lam Ngoc Thao Nguyen, Juan Zhao, Madison Schank, Xindi Dang, Dechao Cao, Sushant Khanal, Bal Krishna Chand Thakuri, Jinyu Zhang, Zeyuan Lu, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Ling Wang, Jonathan P. Moorman, Zhi Q. Yao – 9 June 2021
Hypoxia‐Inducible Exosomes Facilitate Liver‐Tropic Premetastatic Niche in Colorectal Cancer
Hao Sun, Qingtao Meng, Chengyu Shi, Hongbao Yang, Xiaobo Li, Shenshen Wu, Giuseppe Familiari, Michela Relucenti, Michael Aschner, Xuehao Wang, Rui Chen – 9 June 2021
Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity
Ivan Rusyn, Xabier Arzuaga, Russell C. Cattley, J. Christopher Corton, Stephen S. Ferguson, Patricio Godoy, Kathryn Z. Guyton, Neil Kaplowitz, Salman R. Khetani, Ruth A. Roberts, Robert A. Roth, Martyn T. Smith – 8 June 2021 – Hazard identification regarding adverse effects on the liver is a critical step in safety evaluations of drugs and other chemicals. Current testing paradigms for hepatotoxicity rely heavily on preclinical studies in animals and human data (epidemiology and clinical trials).
Surgical Debulking for Refractory Hyperammonemic Encephalopathy in Fibrolamellar Hepatocellular Carcinoma
Vinod Solipuram, Marina Baretti, Alexander Y. Kim, Lucy X. Chen, Jill A. Fahrner, Meral Gunay‐Aygun, Xiao P. Peng, Dylan Hardenbergh, Anna Ferguson, Paige Griffith, Yuxuan Wang, Madelena Brancati, Harish Gopalakrishna, Tomoaki Kato, Chris Shubert, Daniel Laheru, Mark Yarchoan – 8 June 2021
Obituary for Roberto J. Groszmann—The Father of Portal Hypertension
Vijay H. Shah, Yasuko Iwakiri, James L. Boyer – 8 June 2021
Evaluating the Prevention Benefit of HCV Treatment: Modeling the SToP‐C Treatment as Prevention Study in Prisons
Aaron G. Lim, Jack Stone, Behzad Hajarizadeh, Marianne Byrne, Georgina M. Chambers, Natasha K. Martin, Jason Grebely, Gregory J. Dore, Andrew R. Lloyd, Peter Vickerman – 8 June 2021
Transcriptomics Identify Thrombospondin‐2 as a Biomarker for NASH and Advanced Liver Fibrosis
Kazuhiro Kozumi, Takahiro Kodama, Hiroki Murai, Sadatsugu Sakane, Olivier Govaere, Simon Cockell, Daisuke Motooka, Naruyasu Kakita, Yukinori Yamada, Yasuteru Kondo, Yuki Tahata, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Yoshihiro Kamada, Ann K. Daly, Quentin M. Anstee, Tomohide Tatsumi, Eiichi Morii, Tetsuo Takehara – 8 June 2021