<div><p><b>Background:</p> </b><p>Increased intestinal permeability is one of the multiple hits in the pathogenesis of non-alcoholic steatohepatitis (NASH). Bile salt hydrolase (BSH) is a gut bacterial enzyme that hydrolyzes conjugated bile acids (BAs) into unconjugated BAs. Our previous study reported that inhibition of BSH with a gut-restricted small molecule inhibitor, AAA-10, increased conjugated BAs and prevented the development of intestinal permeability and liver steatosis in an early onset, diet-induced rat steatosis model.

<div><p><b>Background: </b>Due to socioeconomic and healthcare access challenges, safety-net patients with liver disease face substantial disadvantages. Little is known about which factors – including psychosocial factors – impact listing for liver transplantation (LT) among the safety-net population.</p>

<div><p><strong>Background</strong>: Anticoagulation (AC) is the mainstay of thromboprophylaxis for stroke prevention in atrial fibrillation (AF) and is recommended. Cirrhosis is a risk factor for AF development; hence, AF is common in patients with cirrhosis. The hemostatic pathways in cirrhosis are imbalanced which makes their response to anticoagulation unpredictable. While Direct-Oral Anticoagulants (DOACs) are shown to be safe and effective in patients with AF without cirrhosis, they are hardly studied in patients with cirrhosis.

<div><p><b>Background: </b>Cirrhosis is characterised by severe liver fibrosis, organ dysfunction and liver-related complications. Presently, there are no approved anti-fibrotic or pro-regenerative therapies for cirrhosis. Preclinical studies have shown bone marrow-derived macrophage injections can resolve hepatic fibrosis, stimulate regeneration and reduce inflammation.

<div><p><b>Background: </b>To evaluate the impact of CT-based deep learning model of hepatic venous pressure gradient (HVPG) on prognosis of hepatocellular carcinoma (HCC) patients treated with transarterial chemoembolization (TACE) and systemic therapy.</p>

<div><p><b><span data-contrast="auto">Background</span></b><span data-contrast="auto">: The “French Medicine Genomic program 2025” is an academic research program that allows to perform whole-genome/exome/RNA sequencing in advanced cancer refractory to systemic treatments to give access to off-labeled therapies adapted to genomic alterations in clinical practice. We reported results in intermediate and advanced hepatocellular carcinoma (HCC) and hepato-cholangiocarcinoma (H-CCK).

<div><p><b>Background:</p> </b><p style="font-weight: 400;">This study was performed to examine the effect of empagliflozin on liver fat content in T2DM patients and in nondiabetic individuals, and the relationship between the decrease in liver fat and other metabolic actions of empagliflozin.</p>

<div><p><b>Background: </b>FDA recommended histopathological end-points for NASH clinical trials may not be fully evaluated by conventional histological staging. Shorter time frames in NASH trials make it difficult to assess changes in treatment-induced fibrosis with current classification systems. Assessment of specific morphological fibrosis parameters and their quantification in specific zones of NASH-CRN classification, can be done by SHG/TPE-based AI platforms.

<div><p><b>Background: </b>Alagille syndrome (ALGS) is a rare, genetic, multisystem disorder in which cholestatic liver disease is common and that may include clinical manifestations of severe pruritus and elevated bile acids (BAs). The efficacy and safety of odevixibat, an ileal bile acid transporter inhibitor, were assessed in patients with ALGS in the phase 3 ASSERT and ASSERT-EXT trials. Using data from these studies, we analyzed the effects of odevixibat on pruritus and BAs over time.</p>

<div><p><b>Background:</p> </b><p>Chronic inflammation due to various etiologies leads to liver fibrosis and subsequently cirrhosis. The liver lymphatic system helps to reduce inflammation. We hypothesized that the liver lymphatic system ameliorates liver fibrosis/cirrhosis.</p>