Regulation of bile acid synthesis. I. Effects of conjugated ursodeoxycholate and cholate on bile acid synthesis in chronic bile fistula rat

Douglas M. Heuman, Carmen R. Hernandez, Philip B. Hylemon, William M. Kubaska, Constance Hartman, Z. Reno Vlahcevic – 1 March 1988 – Bile acid synthesis is thought to be regulated by a negative feedback mechanism which is presumably dependent upon the flux of bile acids in the enterohepatic circulation.

Prognostic indicators in alcoholic cirrhotic men

Christian Gluud, Jens H. Henriksen, The Copenhagen Study Group for Liver Diseases – 1 March 1988 – The relationships between portal pressure, liver function and clinical variables on one hand and development of variceal hemorrhage and death on the other were investigated in 58 men with newly diagnosed alcoholic cirrhosis. Portal pressure was determined during hepatic vein catheterization as wedged minus free hepatic vein pressure, and median pressure was 14 mm Hg (range = 3 to 26 mm Hg).

Tissue localization and kinetics of pit cells or large granular lymphocytes in the liver of rats treated with biological response modifiers

Luc Bouwens, Eddie Wisse – 1 January 1988 – The numbers of Kupffer cells (macrophages) and pit cells (large granular lymphocytes) were counted by light and electron microscopy in perfusion‐fixed liver sinusoids. After a single intravenous injection of the biological response modifiers zymosan, Propionibacterium acnes and OK‐432, a 4‐ to 6‐fold increase in the number of pit cells and a 2‐ to 4‐fold increase in the number of Kupffer cells were observed within a period of 4 to 7 days.

IgA deposition and synthesis in alcoholic liver injury

D. R. Triger – 1 January 1988 – Immunoglobulin deposition in alcoholic and non‐alcoholic liver disease was studied using an indirect immunoperoxidase technique. A continuous pattern of IgA deposition, with IgA outlining the sinusoids, was shown to be a specific and sensitive marker for liver disease caused by alcohol in both cirrhotic and non‐cirrhotic livers. The sensitivity was lowest in cases of alcoholic disease showing fatty change alone.

Serum hyaluronate in primary biliary cirrhosis—A biochemical marker for progressive liver damage

Anders Nyberg, Anna Engström‐Làurent, Lars Lööf – 1 January 1988 – To evaluate serum hyaluronate as a marker for progressive liver injury in patients with primary biliary cirrhosis, a longitudinal study including 48 patients was conducted with a mean follow‐up time of 40 months. The patients were examined every 6 months with a standardized set of conventional liver function tests, and a liver biopsy was performed every year.

Localization of woodchuck hepatitis virus in the liver

Kenji Abe, Takeshi Kurata, Toshio Shikata – 1 January 1988 – Localization of woodchuck hepatitis virus in liver tissue from 10 infected woodchucks was investigated immunohistochemically and ultrastructurally. Woodchuck hepatitis virus surface antigen was detected by immunoperoxidase methods in the cytoplasm of hepato‐cytes with a fine granular and/or inclusion body appearance. Woodchuck hepatitis virus surface antigen positive hepatocytes were often found in the peripheral zone of hepatic lobules.

S‐adenosyl‐L‐methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis

Antonio Martín Duce, Pablo Ortíz, Carmen Cabrero, José M. Mato – 1 January 1988 – We have measured the activity S‐adenosyl‐L‐methio‐nine synthetase in liver biopsies from a group of controls (n = 17) and in 26 cirrhotics (12 alcoholic and 14 posthepatitic). The activity of this enzyme was markedly reduced in the group of cirrhotics (285 ± 32 pmoles per min per mg protein) when compared with that observed in controls (505 ± 37 pmoles per min per mg protein). No differences in S‐adenosyl‐L‐methionine synthetase was observed between both groups of cirrhotics.

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