Katherine S. Koch, Hyam L. Leffert – 1 May 1989 – Two individuals undergoing orthotopic hepatic transplantation received livers from donors who were on average 10 kg smaller than themselves based on recipient ideal body weight. As a result, the donor livers in these 2 cases were 29%‐59% smaller than would be expected had the donor liver and recipient been matched ideally.

Edward S. Feldman, Bruce R. Bacon – 1 May 1989 – Both human porphyria cutanea tarda and experimental hexachlorobenzene‐induced porphyria are associated with hepatic injury and are potentiated by excess hepatic iron. The mechanisms whereby cellular injury occurs and the synergistic role of iron overload are unknown. In the present experiments, we studied hepatic mitochondrial function and lipid peroxidation in rats with hexachlorobenzene‐induced porphyria in which iron loading was achieved by dietary carbonyl iron supplementation.

James H. Lewis, Richard C. Ranard, Anthony Caruso, Lawrence K. Jackson, Florabel Mullick, Kamal G. Ishak, Leonard B. Seeff, Hyman J. Zimmerman – 1 May 1989 – The prevalence of apparent amiodarone‐related hepatic injury in 104 patients followed prospectively is compared to that reported in the literature. Asymptomatic elevation of serum aminotransferase levels was detected in approximately one‐fourth of the patients, a figure similar to the average of reported cases. The frequency of extrahepatic organ toxicity was increased in patients with elevated levels.

Jacqueline Loeper, Véronique Descatoire, Gilles Amouyal, Philippe Lettéron, Dominique Larrey, Dominique Pessayre – 1 May 1989 – Isaxonine and several other drugs transformed by cytochrome P‐450 into reactive metabolites apparently lead to immunoallergic hepatitis in man. Protein epitopes modified by the covalent binding of the metabolites have been proposed as possible targets for the immune response. The purpose of this work was to determine whether covalently bound metabolites are indeed present on hepatocyte plasma membrane proteins.

Fukuo Kondo, Katsunori Wada, Yoshinobu Nagato, Tohru Nakajima, Yoichiro Kondo, Noboru Hirooka, Masaaki Ebara, Masao Ohto, Kunio Okuda – 1 May 1989 – Nodular hepatic lesions detected in 123 patients with chronic liver diseases were subjected to ultrasonically guided needle biopsy. Of these, 94 cases were diagnosed as hepatocellular carcinoma of a moderately or poorly differentiated type with classical histologic features of hepatocellular carcinoma.

Jessica H. Lewis, Franklin A. Bontempo, Sami A. Awad, Yoo Goo Kang, Joseph E. Kiss, Margaret V. Ragni, Joel A. Spero, Thomas E. Starzl – 1 May 1989 – Six intraoperative blood samples were obtained at intervals from each of 100 individuals undergoing their first liver transplants. The patients fell into the following diagnostic categories: postnecrotic cirrhosis 28, primary biliary cirrhosis 20, sclerosing cholangitis 19, miscellaneous diseases 14, carcinoma/neoplasia 12 and fulminant hepatitis 7. Coagulation factor values in the initial (baseline) blood samples varied by patient diagnosis.

Sergio Sainz, Germán Soriano, Carlos Guarner, Pere Coll, Francisco Vilardell, Bruce A. Runyon – 1 April 1989

Bruce F. Scharschmidt, John R. Lake – 1 April 1989 – An impaired sulfoxidation pathway has been implicated in the pathogenesis of chlorpromazine‐induced hepatotoxicity. Since some patients with chronic chlorpromazine‐induced cholestasis may have features of primary biliary cirrhosis, we studied the ability to sulfoxidate the amino acid analogue S‐carboxymethyl‐cysteine in 44 patients with primary biliary cirrhosis and in two control groups—one without liver disease and one with a variety of liver diseases other than primary biliary cirrhosis.

Julius Erdstein, Steven Wisebord, Shaindel Y. Mishkin, Seymour Mishkin – 1 April 1989 – Morris hepatoma 44, whose growth is sensitive to thyroid hormones and prolactin, contains specific receptors for these hormones. In the present experiments, male Buffalo rats bearing Morris hepatoma 7787 were studied to determine the effects of several sex steroid hormones. Castration 1 week postimplantation inhibited tumor growth relative to controls (‐53%). Replacement with testosterone propionate (1 mg per day s.c.

Santiago J. Muñoz, James E. Heubi, William F. Balistreri, Willis C. Maddrey – 1 April 1989 – In contrast to deficiencies of vitamins A, D and K, little is known of the prevalence, clinical manifestations and mechanisms of vitamin E deficiency in adult patients with cholestasis. We measured serum vitamin E levels in 45 patients with primary biliary cirrhosis, 20 with primary sclerosing cholangitis, 9 with cryptogenic cirrhosis and 12 with alcoholic cirrhosis.