Zvi Ackerman, Moshe Y. Flugelman, Yohanan Wax, Daniel Shouval, Micha Levy – 1 August 1989 – Fifty‐six per cent of 118 young adults observed during a recent measles epidemic had some disturbance on liver function tests. Five per cent developed overt jaundice. Patients treated for fever with paracetamol were found to have significantly higher rates of transaminase impairment compared to those treated with dipyrone. Sixty‐five and 58% of patients given paracetamol had elevated ALT and AST levels, respectively.

Yasuni Nakanuma, Motoko Sasaki – 1 August 1989 – The distribution of blood group‐related antigens (A, B, H, Leb) in the intrahepatic biliary tree and hepatocytes was studied by immunoperoxidase techniques. In normal livers, large and septal bile ducts expressed A and B antigens in the cases with comparable blood groups and also expressed H antigen frequently in the cases with blood group O, A or B, and infrequently in the cases with AB. Lea and Leb were found in biliary cells at any level in secretors.

Roderich E. Schwarz, Shunzaburo Iwatsuki, Ronald B. Herberman, Theresa L. Whiteside – 1 August 1989 – Lymphokine‐activated killer cells were generated from peripheral blood mononuclear cells of 33 patients with liver tumors (benign, 6; primary malignant, 10; metastatic, 17) and 10 healthy individuals. Although peripheral blood mononuclear cell yield was significantly lower (p < 0.01) in patients with hepatocellular carcinoma or with metastatic colorectal cancer, natural killer activity in the peripheral blood mononuclear cell fraction was comparable in all groups tested.

Jaap J. Beutler, Hein A. Koomans, Ton J. Rabelink, Carlo A. Gaillard, Jan van Hattum, Peter Boer, Evert J. Dorhout Mees – 1 August 1989 – We compared the natriuretic response to a standard dose of atrial natriuretic factor in nine patients with early cirrhosis (no ascites or edema) with the response in normal subjects displaying a range of baseline sodium excretions due to different sodium intakes (20 mmoles per day, n = 9; 100 mmoles per day, n = 9, and 200 mmoles per day, n = 9).

1 August 1989

Daniel Urbain, Hamphrey R. Ham, Agesilao D'Arienzo, Gabriele Mazzacca – 1 August 1989

S. W. Hosking – 1 August 1989 – Mosaic pattern of gastric mucosa has been reported to be a sensitive and specific criterion for the diagnosis of portal hypertension and an important marker of nonvariceal upper gastrointestinal bleeding. So that the validity of this endoscopic sign could be assessed, 136 patients with portal hypertension, 25 chronic alcoholics without portal hypertension, and 366 controls were carefully endoscoped. Mosaic pattern was significantly (p < 0.01) more common in portal hypertension patients (7.4%) than in controls (1.4%). It was not seen in chronic alcoholics.

Anna Lok – 1 August 1989 – The aetiology of sporadic acute hepatitis in Taiwan was studied in a consecutive series of 273 patients, 209 males and 64 females, aged from < 1 to 73 years. Only eight patients (2.9%) had acute hepatitis A, 36 (13.2%) acute hepatitis B and 57 (20.9%) had acute non‐A, non‐B hepatitis (NANB). The remaining 172 patients (63.0%) were HBsAg positive but antiHBc IgM negative and were classified as acute hepatitis in chronic HBsAg carriers.

Bernd Möller, Uwe Hopf, Roman Stemerowicz, Günther Henze, Hans Gelderblom – 1 August 1989 – Circulating immune complexes composed of HBcAg and anti‐HBc have been demonstrated recently in patients with hepatitis B virus replication. After dissociation of immune complexes by chaotropic ions, HBcAg was quantified radioimmunologically. In the present study, we describe 10 patients with hepatitis B virus replication, absent or delayed anti‐HBc formation and exposed HBcAg in serum. Four of the 10 patients had acute hepatitis, and six patients had chronic persistent hepatitis.

Werner‐J. Mayet, Georg Hess, Guido Gerken, Siegbert Rossol, Rita Voth, Michael Manns, Karl‐Hermann Meyer ZumBüschenfelde – 1 July 1989 – Recombinant human α‐interferon is now under intensive investigation as therapy for chronic Type B hepatitis. Recent reports have suggested that prolonged α‐interferon therapy may induce autoimmune reactions. We have evaluated the problem of autoimmunity related to α‐interferon therapy by testing for 15 different antibodies in the sera of 31 patients treated with α‐interferon.