Marc Espeel, Hanna Mandel, Florence Poggi, Jan A. M. Smeitink, Ronald J. A. Wanders, Ingrid Kerckaert, Rudolf B. H. Schutgens, Jean‐Marie Saudubray, Bwee‐Tien Poll‐The, Frank Roels – 1 August 1995 – Peroxisomal deficiency disorders, which are genetically transmitted, are assumed to be expressed in all cells, and the use of cultured skin fibroblasts for diagnosis and research is based on this assumption. We describe three patients with clinical, biochemical, and microscopic evidence of a peroxisomal disorder.

Joan Saló, Angels Ginès, Luis Anibarro, Wladimiro Jiménez, Ramón Bataller, Joan Clària, Pere Ginès, Francisca Rirvera, Vicente Arroyo, Juan Rodés – 1 August 1995 – It is well known that sodium retention occurs in a significant proportion of patients with cirrhosis despite normal supine plasma levels of renin, aldosterone (ALDO), and norepinephrine (NE). The current study was performed to assess whether this subset of patients also present normal activity of the renin‐aldosterone and sympathetic nervous systems during upright posture in sitting position and moderate physical exercise.

Maria Antonietta Freni, Domenica Artuso, Guido Gerken, Cesarina Spanti, Teresa Marafioti, Nunziata Alessi, Aldo Spadaro, Antonino Ajello, Oscar Ferrau – 1 August 1995 – Intrahepatic lymphocytic aggregates are observed in chronic hepatitis C as well as in autoimmune chronic hepatitis. Autoantibodies and autoimmune manifestations may occur in hepatitis C. It has been suggested that the lymphocytic aggregates play a role in the liver injury of chronic hepatitis C by an immune‐mediated mechanism.

K. Sandy Pang, Ford Barker, Andre Simard, Andreas J. Schwab, Carl A. Goresky – 1 July 1995 – Acetaminophen uptake and conversion in the perfused rat liver to acetaminophen sulfate was studied with the multiple indicator dilution technique (MID).

Ben J. Howard, Roman Pohorecki, Gerald L. Becker, Dennis F. Landers – 1 July 1995 – Both cold and warm ischemia occur during liver transplantation. Hypothermia and Wisconsin solution preserve adenine nucleotide energy status, which is crucial to hepatic function and viability. The volatile anesthetic isoflurane has been shown to preserve energy status in anoxic isolated hepatocytes in warm Krebs solution. The present study examined isoflurane effects on energy status during incubation also in Wisconsin or Krebs‐plusadenosine solution at 37° or 4°.

Carlos Guarner, Bruch A. Runyon – 1 July 1995 – Background. Bacterial infection is a frequent and often fatal complication in patients with cirrhosis. Macro‐phages play an important part in the host defense against infection because their Fcγ receptors recognize antibody‐coated bacteria.

Florence Wong, Laurence Blendis – 1 July 1995

Gennaro D'amico, Luigi Pagliaro, Jaime Bosch – 1 July 1995

Zenghua Ma, Jonathan B. Meddings, Samuel S. Lee – 1 July 1995 – We have previously demonstrated that impairment of cardiac contractility in a rat model of cirrhosis may be secondary to altered cardiac plasma membrane physical properties affecting β‐adrenergic receptor function. It is unclear whether this is caused by the cirrhosis or by the portal hypertension in this model, so we studied cardiomyocyte plasma membrane physical properties, lipid composition, and β‐adrenergic receptor function in a rat model of prehepatic portal hypertension without cirrhosis.

Angels Ginès, Ramon Planas, Paolo Angeli, Carlos Guarner, Francesco Salerno, Pere Ginès, Joan Saló, Nivardo Rodriguez, Eugeni Domènech, Germán Soriano, Luis Anibarro, Miguel Angel Gassull, Angelo Gatta, Vicente Arroyo, Juan Rodés – 1 July 1995 – It has recently been suggested that insertion of a titanium tip at the venous end of the LeVeen shunt drastically reduces the rate of shunt obstruction.