Stephen D. Ryder, John Koskinas, Paolo M. Rizzi, Ian G. McFarlane, Bernard C. Portmann, Nikolai V. Naoumov, Roger Williams – 1 September 1995 – The risk of hepatocellular carcinoma in autoimmune hepatitis is low, even in patients with long‐standing cirrhosis. Because of the increasing recognition of an association of hepatitis C virus (HCV) with autoimmune hepatitis, at least in some geographical areas, and with hepatocellular carcinoma (HCC) (hepatoma), we have examined eight cases (4 male, 4 female) who presented between 1985 and 1993 with hepatoma complicating autoimmune hepatitis.

1 September 1995

Katsuya Shiraki, Koujirou Takase, Yukihiko Tameda, Minoru Hamada, Yoshitane Kosaka, Takeshi Nakano – 1 September 1995 – Levels of two types of lectin‐reactive alpha‐fetoprotein (AFP), designated AFP‐L3 and AFP‐P4+P5, were analyzed with Lens culinaris agglutinin A and AFP‐P4+P5 with erythroagglutinating phytohemagglutinin, respectively, in an attempt to determine the utility and significance of these macromolecules as early indicators of hepatocellular carcinoma during the periodic follow‐up of cirrhotic patients.

Adrian Gadano, Antoine Hadengue, Jean Jacques Widmann, Florence Vachiery, Richard Moreau, Song Yang, Thierry Soupison, Philippe Sogni, Claude Degott, François Durand, Jacques Bernuau, Jacques Belghiti, Serge Erlinger, Jean Pierre Benhamou, Didier Lebrec – 1 August 1995 – Among 68 liver transplant recipients, 190 hemodynamic studies were performed to evaluate the role of sepsis, anemia, acute graft rejection, and persistent portosystemic shunts. The hemodynamic outcome after orthotopic liver transplantation (OLT) in stable patients was also determined.

Harvey L. Sharp – 1 August 1995

Yutaka Inagaki, Sharada Truter, Patricia Greenwel, Marcos Rojkind, Masashi Unoura, Kenichi Kobayashi, Francesco Ramirez – 1 August 1995 – Fat‐storing cells (FSC) are the main producers of type I collagen in both normal and fibrotic livers. In order to elucidate the molecular mechanisms controlling collagen expression in FSC, we examined the transcription of the α2(I) collagen gene (COL1A2) in two distinct FSC clones, CFSC‐2G and CFSC‐5H, derived from a single CCl4‐induced cirrhotic liver.

Laurie C. Miller, Archna Sharma, Augusta F. McKusick, Joseph P. Tassoni, Charles A. Dinarello, Marshall M. Kaplan – 1 August 1995 – Primary biliary cirrhosis (PBC) is a chronic, progressive, cholestatic liver disease. Interleukin‐1β (IL‐1β) may play a role in the pathogenesis of PBC by contributing to altered immune function and fibrosis. Colchicine or methotrexate has some beneficial effects in the treatment of PBC, and also affects interleukin‐1 (IL‐1).

Gin‐Ho Lo, Kwok‐Hung Lai, Jing‐Shiung Cheng, Jia‐Huey Hwu, Chia‐Fu Chang, Sam‐Ming Chen, Hung‐Ting Chiang – 1 August 1995 – We conducted a prospective, randomized trial comparing sclerotherapy and ligation in 120 patients with acute bleeding of esophageal varices. All the patients were cirrhotic, 59 received sclerotherapy, and 61 received ligation. Treatment was repeated regularly until the varices were obliterated. The mean follow‐up period was 295 ± 120 days and 310 ± 105 days for the sclerotherapy and ligation groups, respectively.

Shunji Narumi, John P. Roberts, Jean C. Emond, John Lake, Nancy L. Ascher – 1 August 1995 – The clinical course of 37 patients who underwent 46 liver transplantations for primary (n = 33) and secondary (n = 4) sclerosing cholangitis was reviewed. The median follow‐up was 37 months. The patient and graft survivals for patients with primary sclerosing cholangitis at 1, 2, and 5 years were 96.9%, 91.6%, 87.9%, and 83.1%, 74.2%, 65.2%, respectively.

Bruno Turlin, Frédéric Juguet, Romain Moirand, Danielle Le Quilleuc, Olivier Loréal, Jean‐Pierre Campion, Bernard Launois, Marie‐Paule Ramée, Pierre Brissot, Yves Deugnier – 1 August 1995 – Iron was systematically studied in the nontumorous liver of 24 patients with hepatocellular carcinoma (HCC) developed on a noncirrhotic liver compared with 4 control groups (cirrhosis with and without HCC, liver metastasis, and normal liver) matched according to age, sex, and presence of chronic alcoholism.