Hepatobiliary transport of hepatic 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase inhibitors conjugated with bile acids

Ernst Petzinger, Lutz Nickau, Jurgen A. Horz, Siegfried Schulz, Gunther Wess, Alfons Enhsen, Eugen Falk, Karl‐Heinz Baringhaus, Heiner Glombik, Axel Hoffmann, Stefan Müllner, Georg Neckermann, Werner Kramer – 1 December 1995 – To obtain prodrugs with affinity to liver parenchymal cells, the hepatic 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors HR 780 and lovastatin (syn. mevinolin) were conjugated with the bile acids cholic acid, taurocholic acid, and glycocholic acid.

Ciprofloxacin prevents the inhibitory effects of acute ethanol exposure on hepatic regeneration in the rat

Gerald Y. Minuk, Tony Gauthier, Xin K. Zhang, Gu Qi Wang, Norman M. Pettigrew, Frank J. Burczynski – 1 December 1995 – To determine whether the inhibitory effects of ethanol on hepatic regeneration could be prevented by ciprofloxacin, a fluroquinolone antibiotic with gammaaminobutyric acid (GABAA), receptor antagonist properties, adult, male Sprague‐Dawley rats (n = 6‐8/group) received intraperitoneal injections of saline, putrescine (a hepatic growth promotor, 50 mg/kg), or ciprofloxacin (100 mg/kg), followed 1 hour later by gastric gavage with saline or ethanol (5 g/kg).

Evidence for the presence of an inactive precursor of human hepatocyte growth factor in plasma and sera of patients with liver diseases

Naokatu Arakaki, Shuichi Kawakami, Osamu Nakamura, Tomokazu Ohnishi, Hiroomi Miyazaki, Takehisa Ishii, Hirohito Tsubouchi, Yasushi Daikuhara – 1 December 1995 – Human hepatocyte growth factor (hHGF), which is now known to be the same protein as the scatter factor and the tumor cytotoxic factor, is a heterodimeric protein with one heavy chain and one light chain linked together by a disulfide bond, and is thought to be involved in liver regeneration.

Changes in platelet kinetics after a partial splenic arterial embolization in cirrhotic patients with hypersplenism

Hideya Noguchi, Kenji Hirai, Yoshinori Aoki, Kenji Sakata, Kyuichi Tanikawa – 1 December 1995 – We performed a partial splenic arterial embolization in 22 patients with cirrhosis associated with thrombocy‐topenia and then evaluated the changes in platelet kinetics after undergoing the procedure using 111In‐tropolone–labeled platelets. The controls consisted of eight chronic hepatitis patients who showed a normal platelet count and normal spleen size. The mean splenic infarction ratio after the procedure was 54.9%.

Management of focal nodular hyperplasia and hepatocellular adenoma in young women: A series of 41 patients with clinical, radiological, and pathological correlations

Daniel Cherqui, Alain Rahmouni, Frédéric Charlotte, Hatem Boulahdour, Michel Meignan, Pierre‐Louis Fagniez, Elie‐Serge Zafrani, Didier Mathieu, Daniel Dhumeaux, Jean‐Michel Métreau – 1 December 1995 – Preoperative distinction between focal nodular hyperplasia (FNH) that should be managed conservatively and hepatocellular adenoma (HA) that should be resected remains difficult. The result is controversial management of these patients.

Portal vein embolization with steel coils and absolute ethanol: A comparative experimental study with canine liver

Koichiro Yamakado, Kan Takeda, Yoshiya Nishide, Jugangu Jin, Kaname Matsumura, Atsuhiro Nakatsuka, Tadanori Hirano, Noriyuki Kato, Tsuyoshi Nakagawa – 1 December 1995 – Portal vein embolization (PVE) is expected to have an adjuvant effect on the treatment of human liver tumors with transcatheter hepatic arterial embolization (TAE). In this experimental study, PVE was tried using two kinds of embolic materials, steel coils (coils) and absolute ethanol (ethanol). The aim of this article is to compare the effectiveness between the two methods.

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