P Rajvanshi, A Kerr, K K Bhargava, R D Burk, S Gupta – 1 March 1996 – The feasibility of liver repopulation with hepatocytes has been shown, although clinical applications demand significant hepatic replacement. To show whether portal vascular bed in large animals could accomodate a greater cell number, we analyzed liver repopulation in syngeneic Fischer 344 rats deficient in dipeptidyl peptidase IV. This system allowed localization of transplanted normal hepatocytes in liver or various ectopic sites, as well as dual studies for analysis of gene expression.

1 March 1996

Nicolas Jabbour, Albert B. Zajko, Philip D. Orons, William Irish, Fabio Bartoli, Wallis J. Marsh, Gerald D. Dodd, Luca Aldreghitti, Joann Colangelo, Jorge Rakela, John J. Fung – 1 March 1996 – Transjugular intrahepatic portosystemic shunt (TIPS) is becoming an accepted procedure as a bridge to orthotopic liver transplantation (OLT) in patients with end‐stage liver disease (ESLD) and bleeding from portal hypertension. It allows the immediate control of acute bleeding and decreases the risk of recurrent acute bleeding while the patient is awaiting OLT.

H Jaeschke, N A Essani, M A Fisher, S L Vonderfecht, A Farhood, C W Smith – 1 March 1996 – Neutrophil‐induced liver injury during endotoxemia is dependent on the adhesion molecules Mac‐1 (CD11b/CD18) on neutrophils and its counterreceptor on endothelial cells and hepatocytes, intercellular adhesion molecule 1 (ICAM‐1). To investigate a potential release of a soluble form of ICAM‐1 (sICAM‐1), animals received 100 μg/kg Salmonella abortus equi endotoxin alone or in combination with 700 mg/kg galactosamine.

M Mise, S Arii, H Higashituji, M Furutani, M Niwano, T Harada, S Ishigami, Y Toda, H Nakayama, M Fukumoto, J Fujita, M Imamura – 1 March 1996 – Hepatocellular carcinoma (HCC) is a typical hypervascular tumor. However, the relationship between the vascularity of HCC and the expression of angiogenic factors has not been investigated. In addition, no detailed studies have examined the possible involvement of angiogenic factors in the grade of malignancy of HCC.

C Hamon‐Benais, O Ingster, B Terris, M Couturier‐Turpin, A Bernheim, G Feldmann – 1 March 1996 – Although numerous allelic chromosome losses have been reported in hepatocellular carcinomas (HCC), chromosome analysis by cytogenetic methods has rarely been performed in these tumors, unlike other solid malignant tumors.

Douglas Quan, William J. Wall – 1 March 1996 – To evaluate the safety of temporary hepatic inflow occlusion during major liver resection, we reviewed 71 consecutive noncirrhotic patients who underwent elective liver resection using this technique. There were 27 males and 44 females (mean age, 54.4 years), the majority of whom had hepatic malignancies. There were 31 right hepatectomies, 21 left hepatectomies, and 19 extended right hepatectomies.

L S Friedman – 1 March 1996

J Vassy, M Beil, T Irinopoulou, J P Rigaut – 1 March 1996 – Recent reports suggest that not only chemical but also mechanical influences from the cellular environment could have profound effects on gene activity and could act on cell differentiation and proliferation. These mechanisms involve a tissue matrix system, which includes extracellular matrix, nuclear matrix, and cytoskeleton.

M Yamamoto, K Ogawa, M Morita, K Fukuda, Y Komatsu – 1 March 1996 – Transforming growth factor β1 (TGF‐β1) is reported to play an important role in the induction of liver cell apoptosis. In this report, we demonstrate that TGF‐β1 induces apoptosis in a rat Morris hepatoma McA‐RH8994 cell line and rat primary cultured hepatocytes at similar doses and in a similar manner. Using McA‐RH8994 cells, we screened a number of chemical reagents, aqueous extracts of crude drugs, and herbal medicines for their inhibitory activities on TGF‐β1‐induced apoptosis.