P D Berk – 1 July 1996

A Piperno, C Arosio, S Fargion, A Roetto, C Nicoli, D Girelli, L Sbaiz, P Gasparini, G Boari, M Sampietro, C Camaschella – 1 July 1996 – We evaluate the relation between genotype and phenotype in 47 Italian male patients with homozygous genetic hemochromatosis (GH). Phenotype evaluation was based on the ratio of amount of iron removed (IR) by phlebotomy and age (IR/age). Patients were divided in two classes of phenotype expression: class I included 26 patients with less severe iron overload (IR/age ≤0.33) and class II included 21 patients with a more marked one (IR/age >0.33).

J Kulisevsky, J Pujol, J Deus, J Balanzó, A Pujol – 1 July 1996

S Sadallah, E Giostra, G Mentha, J A Schifferli – 1 July 1996 – Complement receptor type 1 (CR1) is an integral membrane protein of many hematopoietic cells and is found in a soluble form in plasma. Preliminary data have indicated that soluble complement receptor 1 (sCR1) levels in serum were increased in patients with cirrhosis. In this study, sCR1 was measured in patients with various liver diseases with a newly established enzyme‐linked immunosorbent assay (ELISA).

K Ishibashi, T Kashiwagi, A Ito, Y Tanaka, M Nagasawa, T Toyama, S Ozaki, M Naito, M Azuma – 1 July 1996 – We serially measured the levels of serum N‐terminal peptide of type III procollagen (PIIINP), the 7S domain of type IV collagen (IV‐7S), and hyaluronate (HA) before (0 month), at the end (6 months), and 24 weeks after the end of interferon therapy (12 months) in patients with chronic hepatitis type C to estimate the effects of interferon alfa (IFN‐alpha) on serum levels of hepatic fibrogenesis markers.

Michael J. Krowka – 1 July 1996

1 July 1996

M Yamauchi, Y Maezawa, Y Mizuhara, M Ohata, J Hirakawa, H Nakajima, G Toda – 1 July 1996

S C Lu, J Cai, J Kuhlenkamp, W Sun, H Takikawa, O Takenaka, T Horie, J Yi, N Kaplowitz – 1 July 1996 – Eisai hyperbilirubinemic rats (EHBR) are mutant Sprague‐Dawley rats that exhibit impaired biliary organic anion and reduced glutathione (GSH) secretion. In addition, liver GSH levels are twice that of age‐ matched controls. The mechanisms for the defect in biliary GSH secretion and the increase in cell GSH are not fully understood. We previously showed that canalicular membrane‐enriched vesicles isolated from EHBR livers exhibited normal GSH transport.

Eric Koffi, Vincent Moutardier, Alain Sauvanet, Roger Noun, Jean François Fléjou, Jacques Belghiti – 1 July 1996 – Cutaneous metastases arising along the exit site of an abdominal drain in one patient and within the operative wound in two others after resection of a hepatocellular carcinoma (HCC) are reported. All patients underwent curative hepatic resection, and cutaneous metastases occurred 9, 12, and 22 months after surgery respectively. Cutaneous metastases were not associated with intrahepatic recurrence and were treated by local excision.