K Tokushige, T Wakita, C Pachuk, D Moradpour, D B Weiner, V R Zurawski, J R Wands – 1 July 1996 – Hepatitis C virus (HCV) is a major worldwide cause of acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The development of vaccines against HCV have been complicated by the high variability of the envelope region, and it is likely that the cellular immune responses to viral structural proteins may be important for eradicating persistent viral infection.

E Walter, R Keist, B Niederöst, I Pult, H E Blum – 1 July 1996 – For the systematic analysis of various clinical and molecular aspects of hepatitis B virus (HBV) infection, an experimental small animal system of HBV infection would be a great advance. The susceptibility to HBV infection, therefore, of hepatocytes from the tree shrew species tupaia belangeri was studied in vitro and in vivo. Primary hepatocytes isolated from livers of tupaias can be reproducibly infected with HBV.

Stanley A. Nasraway – 1 July 1996

Thomas S. Helling, R. Scott Strobach – 1 July 1996 – This study is a case report and literature review of the surgical approach to papillary lesions of the biliary tract exclusive of the ampulla of Vater. Papillary lesions of the bile ducts, exclusive of the ampulla of Vater, are distinctly uncommon but, because of their unpredictable and aggressive behavior, pose challenging problems for the surgeon.

Martin Krüger, Hans Ludger Tillmann, Christian Trautwein, Ulrike Bode, Karl Oldhafer, Hansjörg Maschek, Klaus H. W. Böker, Christoph E. Broelsch, Rudolf Pichlmayr, Michael P. Manns – 1 July 1996 – Despite hepatitis B immunoprophylaxis hepatitis B virus (HBV) recurrence is a frequent and often fatal complication after orthotopic liver transplantation (OLT). The purine nucleoside analogues penciclovir and its oral form famciclovir (FCV) proved to be well tolerated and effective against herpes simplex and zoster virus infections.

L S Friedman – 1 July 1996

M Lekehal, D Pessayre, J M Lereau, C Moulis, I Fourasté, D Fau – 1 July 1996 – Several herbal remedies have produced hepatitis in humans. The medicinal plant, germander, was recalled after its use as an adjuvant to slimming diets resulted in an epidemic of hepatitis in France. We studied the hepatotoxicity of germander in isolated rat hepatocytes.

R H Moseley, H Takeda, L J Zugger – 1 July 1996 – Previous studies have demonstrated several pathways for the sinusoidal uptake of endogenous and exogenous organic cations, including two distinct organic cation:H+ exchanges and a separate carrier‐mediated system driven by the inside‐negative membrane potential. In this study, the driving force(s) for the uptake of the endogenous quaternary amine, choline, were determined in rat liver basolateral plasma membrane (blLPM) vesicles.

1 July 1996

K Preisegger, C Stumptner, D Riegelnegg, P C Brown, J A Silverman, S S Thorgeirsson, H Denk – 1 July 1996 – Mallory bodies (MBs) are characteristic morphological features of alcoholic hepatitis and are also found in other chronic liver disorders and hepatocellular neoplasms. MBs can be produced in mouse liver by chronic administration of the porphyrinogenic drugs griseofulvin (GF) and 3,5‐diethoxy‐carbonyl‐1,4‐dihydrocollidine (DDC). The mechanisms causing the formation of MBs are poorly understood, and the significance of MB formation during the course of liver disease remains unclear.