Split and whole liver transplantation outcomes: A comparative cohort study

Massimo Cardillo, Nicola De Fazio, Paola Pedotti, Tullia De Feo, Luigi Rainero Fassati, Vincenzo Mazzaferro, Michele Colledan, Bruno Gridelli, Lucio Caccamo, Luciano DeCarlis, Umberto Valente, Enzo Andorno, Mariangelo Cossolini, Cristiano Martini, Adelmo Antonucci, Umberto Cillo, Giacomo Zanus, Umberto Baccarani, Mario Scalamogna, NITp Liver Transplantation Working Group – 23 February 2006 – A specific split liver transplantation (SLT) program has been pursued in the North Italian Transplant program (NITp) since November 1997.

Characterization of human liver dendritic cells in liver grafts and perfusates

Brenda M. Bosma, Herold J. Metselaar, Shanta Mancham, Partrick P.C. Boor, Johannes G. Kusters, Geert Kazemier, Hugo W. Tilanus, Ernst J. Kuipers, Jaap Kwekkeboom – 23 February 2006 – It is generally accepted that donor myeloid dendritic cells (MDC) are the main instigators of acute rejection after organ transplantation. The aim of the present study was to characterize MDC in human donor livers using liver grafts and perfusates as a source. Perfusates were collected during ex vivo vascular perfusion of liver grafts pretransplantation.

Regional sharing for adult status 1 candidates: Reduction in waitlist mortality

Kenneth Washburn, Ann Harper, Goran Klintmalm, John Goss, Glenn Halff – 23 February 2006 – The intent of regional sharing for status 1 candidates is to promote timely access to donor livers. Presumably this decreases waitlist mortality. Little published data exists that supports this policy. Organ Procurement and Transplantation Network data was used to calculate region 4 and national adult waitlist death and transplant rates 4 yr prior to (period A) and after (period B) implementation of the sharing agreement in July 1999.

Interventional radiology in liver transplantation

Nikhil B. Amesur, Albert B. Zajko – 23 February 2006 – Improvements in surgical technique, advances in the field of immunosuppresion and the early diagnosis and treatment of complications related to liver transplantation have all led to prolonged survival after liver transplantation. In particular, advances in diagnostic and interventional radiology have allowed the Interventional Radiologist, as part of the transplant team, to intervene early in patients presenting with complications related to organ transplant with resultant increase in graft and patient survival.

Thrombopoietin in postoperative thrombocytopenia following living donor hepatectomy

Yoshihide Nagasako, Meang Bong Jin, Hiroshi Miyazaki, Masato Nakayama, Tsuyoshi Shimamura, Hiroyuki Furukawa, Michiaki Matushita, Satoru Todo – 23 February 2006 – Thrombocytopenia is a frequent finding following living donor hepatectomy. It appears more pronounced in right graft donors than in left graft donors. This study analyzed postoperative thrombocytopenia in 20 living liver donors and examined the change of endogenous thrombopoietin (TPO) in its recovery.

Liver transplantation for gastroenteropancreatic neuroendocrine cancers: Defining selection criteria to improve survival

Frederike G.I. van Vilsteren, Edwina S. Baskin‐Bey, David M. Nagorney, Schuyler O. Sanderson, Walter K. Kremers, Charles B. Rosen, Gregory J. Gores, Timothy J. Hobday – 23 February 2006 – Liver transplantation for gastroenteropancreatic neuroendocrine cancer (GEP) is controversial. The aim of this study was to assess patient outcomes after liver transplantation for hepatic metastases from GEP. Medical records of patients who underwent liver transplantation for GEP were reviewed. Immunohistochemistry for assessing the Ki67 proliferation index was performed on explanted liver tissue.

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