Acute humoral rejection and C4d immunostaining in ABO blood type‐incompatible liver transplantation

Hironori Haga, Hiroto Egawa, Yasuhiro Fujimoto, Mikiko Ueda, Aya Miyagawa‐Hayashino, Takaki Sakurai, Tomoko Okuno, Itsuko Koyanagi, Yasutsugu Takada, Toshiaki Manabe – 23 February 2006 – Complement C4d deposition in graft capillaries has been reported to be associated with antibody‐mediated rejection in kidney and other solid organ transplantation. The correlation of C4d deposits and humoral rejection in liver transplants, however, is not well understood.

Natural killer cells: Primary target for hepatitis C virus immune evasion strategies?

Lucy Golden‐Mason, Hugo R. Rosen – 23 February 2006 – Liver cirrhosis and hepatocellular carcinoma secondary to chronic hepatitis C virus (HCV) infection requiring transplantation represents a significant public health problem. The most remarkable feature of hepatitis C virus is the ability to establish chronic infection in the vast majority of cases. Efforts to define clinical correlates of HCV persistence have focused primarily on CD4 and CD8 T cell responses. Until recently, the role of innate immunity in determining the outcome of HCV infection had received relatively little attention.

The immunological monitoring of alloreactive responses in liver transplant recipients: A review

Raymond Reding, Jérémie Gras, Dinh Quang Truong, Grégoire Wieërs, Dominique Latinne – 23 February 2006 – The aim of this work is to review the current knowledge in the field of immunological monitoring of allogenic responsiveness in clinical liver transplantation. When compared to other solid‐organ transplants, liver allografts are considered as immunologically privileged, and, accordingly, constitute a favorable setting to develop experimental as well as clinical strategies for minimization of immunosuppression and even induction of operational tolerance.

Clinical outcomes from hepatic artery stenting in liver transplantation

Takehisa Ueno, Greg Jones, Adrian Martin, Toru Ikegami, Edmund Q. Sanchez, Srinath Chinnakotla, Henry B. Randall, Marlon F. Levy, Robert M. Goldstein, Goran B. Klintmalm – 23 February 2006 – Hepatic artery stenosis after liver transplantation may affect liver function and result in hepatic artery thrombosis. Surgical reconstruction has been the first choice for treatment. Interventional radiologic technique can be used, but there is no report on long‐term outcome. The aim of this paper is to assess current outcome and complications of hepatic artery stenting.

Caroli's disease and orthotopic liver transplantation

Shahid Habib, Obaid Shakil, Osvaldo F. Couto, Anthony J. Demetris, John J. Fung, Amadeo Marcos, Kapil Chopra – 23 February 2006 – Caroli's disease is a rare congenital hepatic disease, characterized by segmental dilatation of the biliary tree. Patients who have recurrent bouts of biliary infection, particularly those with complications related to portal hypertension, may require orthotopic liver transplantation (OLT). Few case reports have described the outcome of OLT in patients with Caroli's disease and to date there is no large series reported in the literature.

“Hepar divisum”– as a rare donor complication after intraoperative mortality of the recipient of an intended living donor liver transplantation

Silvio Nadalin, Massimo Malagó, Giuliano Testa, Randolph Schaffer, Georgios C. Sotiropoulos, Andrea Frilling, Christoph E. Broelsch – 23 February 2006 – In this study, we present our experience with 4 healthy donors having the rare condition of “hepar divisum” after the intraoperative death of the recipient of an intended right adult living donor liver transplantation (LDLT). The study included 4 donors and 4 intended right LDLT recipients affected by neuroendocrine tumor (n = 2), hepatocellular carcinoma (n = 1), and cryptogenic cirrhosis (n = 1). All 4 recipients died intraoperatively.

Percutaneous transluminal angioplasty for hepatic artery stenosis after living donor liver transplantation

Yoshihisa Kodama, Yusuke Sakuhara, Daisuke Abo, Tsuyoshi Shimamura, Hiroyuki Furukawa, Satoru Todo, Kazuo Miyasaka – 23 February 2006 – The purpose of this study was to evaluate the efficacy of percutaneous transluminal angioplasty (PTA) for treatment of hepatic artery stenosis after living donor liver transplantation. Eighteen patients with hepatic artery stenosis after living donor liver transplantation were included in this study. The success rate and complications of PTA and recurrent stenosis of the hepatic artery were evaluated.

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