An MLCK‐dependent window in late G1 controls S phase entry of proliferating rodent hepatocytes via ERK‐p70S6K pathway

Anne Bessard, Alexandre Coutant, Claude Rescan, Frédéric Ezan, Christophe Frémin, Brice Courselaud, Gennady Ilyin, Georges Baffet – 23 June 2006 – We show that MLCK (myosin light chain kinase) plays a key role in cell cycle progression of hepatocytes: either chemical inhibitor ML7 or RNA interference led to blockade of cyclin D1 expression and DNA replication, providing evidence that MLCK regulated S phase entry. Conversely, inhibition of RhoK by specific inhibitor Y27632 or RhoK dominant‐negative vector did not influence progression in late G1 and S phase entry.

Multiple polymorphic loci determine basal hepatic and splenic iron status in mice

Gemma R. Grant, Susan W. Robinson, Richard E. Edwards, Bruce Clothier, Reginald Davies, David J. Judah, Karl W. Broman, Andrew G. Smith – 23 June 2006 – Polymorphisms of genes linked to iron metabolism may account for individual variability in hemochromatosis and iron status connected with liver and cardiovascular diseases, cancers, toxicity, and infection. Mouse strains exhibit marked differences in levels of non‐heme iron, with C57BL/6J and SWR showing low and high levels, respectively.

A double‐blind randomized trial of adefovir dipivoxil in Chinese subjects with HBeAg‐positive chronic hepatitis B

MinDe Zeng, YiMin Mao, GuangBi Yao, Hao Wang, JinLin Hou, YaoZong Wang, Beulah N. Ji, Chai‐Ni P. Chang, Keith F. Barker – 23 June 2006 – Four hundred and eighty Chinese subjects with hepatitis B e antigen (HBeAg)–positive chronic hepatitis B (CHB) were enrolled in a multicenter, double‐blind, randomized, placebo‐controlled study of adefovir dipivoxil (ADV) 10 mg once daily.

Management of patients with biliary atresia in France: Results of a decentralized policy 1986‐2002

Marie‐Odile Serinet, Pierre Broué, Emmanuel Jacquemin, Alain Lachaux, Jacques Sarles, Frédéric Gottrand, Frédéric Gauthier, Christophe Chardot – 23 June 2006 – This study analyzed the results of the decentralized management of biliary atresia (BA) in France, where an improved collaboration between centers has been promoted since 1997. Results were compared to those obtained in England and Wales, where BA patients have been centralized in three designated centers since 1999.

Subscribe to