Mas‐related G protein‐coupled receptor type D antagonism improves portal hypertension in cirrhotic rats

Lakmie S. Gunarathne, Indu G. Rajapaksha, Stephen Casey, Tawar Qaradakhi, Anthony Zulli, Harinda Rajapaksha, Jonel Trebicka, Peter W. Angus, Chandana B. Herath – 19 May 2022 – Splanchnic vasodilatation contributes to the development and aggravation of portal hypertension (PHT). We previously demonstrated that in cirrhosis, angiotensin‐ mediates splanchnic vasodilatation through the Mas receptor (MasR).

Prophylactic effect of tenofovir on viral reactivation in immunocompromised pregnant women living with hepatitis B virus

Le Zhang, Shaoying Yang, Yongfu Yu, Suli Wang, Yuetian Yu, Yi Jin, Aimin Zhao, Yimin Mao, Liangjing Lu – 19 May 2022 – The appropriate prophylaxis for hepatitis B virus reactivation (HBVr) during gestation for immunocompromised pregnant women has yet to be determined. The prophylactic efficacy and safety of tenofovir disoproxil fumarate (TDF) in hepatitis B surface antigen (HBsAg)–positive patients and the HBVr risk in hepatitis B core antibody (HBcAb)–positive patients during gestation were investigated.

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