Sihong Song, Rafal P. Witek, Yuanqing Lu, Young‐Kook Choi, Donghang Zheng, Marda Jorgensen, Chengwen Li, Terence R. Flotte, Byron E. Petersen – 7 March 2007 – Allogeneic stem cell‐based transplants may be limited by allograft rejection, as is seen with conventional organ transplantation. One way to avert such a response is to use autologous stem cells, but that may carry the risk of recurrence of the original disease, particularly in the context of a genetic defect.

Kung‐Chia Young, Karen L. Lindsay, Ki‐Jeong Lee, Wen‐Chun Liu, Jian‐Wen He, Susan L. Milstein, Michael M. C. Lai – 7 March 2007 – Ribavirin (RBV), a guanosine analogue, has been suggested to exert an antiviral action against hepatitis C virus (HCV) by causing lethal mutations and suppressing RNA polymerase in vitro, but the mechanism of its clinical therapeutic effects is currently unknown.

David R. Nelson, Zhengkun Tu, Consuelo Soldevila‐Pico, Manal Abdelmalek, Haizhen Zhu, Yi Ling Xu, Roniel Cabrera, Chen Liu, Gary L. Davis – 7 March 2007 – An imbalance in Th1 and Th2 cytokine production is implicated in disease progression of HCV. Our aim was to determine the effect of IL‐10 administration in patients with HCV‐related liver disease. Thirty patients with advanced fibrosis who had failed antiviral therapy were enrolled in a 12‐month treatment regimen with SQ IL‐10 given daily or thrice weekly. Liver biopsies were performed before and after therapy.

Zhi Hong – 7 March 2007

7 March 2007

O Hermine, F Lefrere, Jp Bronowicki, X Mariette, K Jondeau, V Eclache‐Saudreau, B Delmas, F Valensi, P Cacoub, C Brechot, B Varet, X Troussard, Francesco Negro – 7 March 2007 – Some epidemiologic studies suggest a link between hepatitis C virus (HCV) infection and some B‐cell non‐Hodgkin's lymphomas. We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection.

Hirayuki Enomoto, Kenya Yoshida, Yoshihiko Kishima, Taisei Kinoshita, Mitsunari Yamamoto, Allen D. Everett, Atsushi Miyajima, Hideji Nakamura – 7 March 2007 – Hepatoma‐derived growth factor (HDGF) is a heparin‐binding protein, which has been purified from the conditioned media of HuH‐7 hepatoma cells. Recent studies have suggested the involvement of HDGF in development of the kidney and cardiovascular systems. In the present study, we investigated the possibility that HDGF was also involved in liver development.

Rafael Bañares, Eduardo Moitinho, Ana Matilla, Juan Carlos García‐Pagán, José Luis Lampreave, Carlos Piera, Juan G. Abraldes, Alejandro De Diego, Agustín Albillos, Jaime Bosch – 7 March 2007 – Short‐term carvedilol administration is more powerful than propranolol in decreasing hepatic venous pressure gradient (HVPG) in cirrhotic patients, but induces arterial hypotension that may prevent its long‐term use in portal hypertensive patients. This study compared the HVPG reduction and safety of long‐term carvedilol and propranolol.

Koko Bate Aborsangaya, Iga Dembinski, Suresh Khatkar, Martin Prince Alphonse, Peter Nickerson, Julia D. Rempel – 26 February 2007 – The host immune response is a critical determinant in viral infection outcome. Epidemiological studies indicate that North American indigenous peoples are more resistant to chronic HCV infection than other populations. Due to the prominence of IL‐10 in chronic HCV infection, we investigated the genetic tendency to produce IL‐10 in Caucasian (CA) and First Nation (FN) populations.

Paul J. Pockros, Lennox Jeffers, Nezam Afdhal, Zachary D. Goodman, David Nelson, Robert G. Gish, K. Rajender Reddy, Robert Reindollar, Maribel Rodriguez‐Torres, Sarah Sullivan, Lawrence M. Blatt, Sima Faris‐Young – 26 February 2007 – Interferon‐γ1b (IFN‐γ1b) is a pleiotropic cytokine that displays antifibrotic, antiviral, and antiproliferative activity.