Induction of long‐term liver allograft survival by delayed immunosuppression is dependent on interleukin‐10

Zhen Fan Yang, Patricia Ngai, Chi Keung Lau, David W. Ho, Ka Ho Tam, Chi Tat Lam, Ronnie T. Poon, Sheung Tat Fan – 29 March 2007 – This study aims to investigate the potential role of endogenous interleukin (IL)‐10 in long‐term liver allograft survival induced by delayed immunosuppression (FK506 days 2‐7). Liver transplantation was performed by using Dark Agouti and Lewis rats as donors and recipients, respectively. The delayed immunosuppression protocol induced indefinite allograft survival.

Recurrent hepatocellular carcinoma after transplantation: Use of a pathological score on explanted livers to predict recurrence

Jeremy R. Parfitt, Paul Marotta, Mohammed AlGhamdi, William Wall, Anand Khakhar, Neville G. Suskin, Douglas Quan, Vivian McAllister, Cam Ghent, Mark Levstik, Carolyn McLean, Subrata Chakrabarti, Bertha Garcia, David K. Driman – 29 March 2007 – Milan and University of California at San Francisco (UCSF) criteria are used to select patients with hepatocellular carcinoma (HCC) for liver transplantation (LT). Recurrent HCC is a significant cause of death. There is no widely accepted pathological assessment strategy to predict recurrent HCC after transplantation.

Combined HLA‐DR and ‐DQ disparity is associated with a stable course of ulcerative colitis after liver transplantation for primary sclerosing cholangitis

Evangelos Cholongitas, George V. Papatheodoridis, Paola Zappoli, Athanasios Giannakopoulos, David Patch, Laura Marelli, Vibhakorn Shusang, George Kalambokis, Graham Shirling, Nancy Rolando, A. K. Burroughs – 29 March 2007 – Combined disparity of human leukocyte antigen (HLA)‐DR and ‐DQ between mother and fetus is associated with less severe ulcerative colitis (UC) during pregnancy. We evaluated whether donor‐recipient HLA disparity after liver transplantation (LT) affects UC in patients with primary sclerosing cholangitis (PSC).

Recipient and donor factors influence the incidence of graft‐vs.‐host disease in liver transplant patients

Edie Y. Chan, Anne M. Larson, Terry B. Gernsheimer, Kris V. Kowdley, Robert L. Carithers, Jorge D. Reyes, James D. Perkins – 29 March 2007 – Acute cellular graft‐vs.‐host disease (GVHD) following liver transplantation has an incidence of 1 to 2% and a mortality rate of 85%. Our aim was to identify a patient population at high risk for developing GVHD using a large clinical database to study both recipient and donor factors. We compared our liver transplant patients who developed GVHD to those that did not for recipient and donor factors and combinations of factors.

Working up donors for high‐urgency and elective adult‐to‐adult live donor liver transplantation

See Ching Chan, Sheung Tat Fan, Chi Leung Liu, Chung Mau Lo, Banny K. Lam, Evelyn W. Lee – 29 March 2007 – Donor workup for adult‐to‐adult live donor liver transplantation is done to ensure that the donor remains physically and psychologically healthy after saving or improving the life of the recipient. Even though two‐thirds of the liver transplants in our center were from live donors, this life‐saving procedure remains a mere treatment option, given the magnitude of the donor operation with the associated donor risks.

Tissue factor‐dependent procoagulant activity of isolated human hepatocytes: Relevance to liver cell transplantation

Xavier Stéphenne, Olivier Vosters, Mustapha Najimi, Claire Beuneu, Dung Khuu Ngoc, Walter Wijns, Michel Goldman, Etienne M. Sokal – 29 March 2007 – Liver cell transplantation (LCT) aims to correct inborn liver function defects by infusing metabolically active cells into the diseased liver. Further improvement in LCT might depend on the prevention of early loss of transplanted cells.

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