Richard B. Freeman – 27 July 2007

Tomasz Laskus, Jeffrey Wilkinson, Roksana Karim, Wendy Mack, Marek Radkowski, Marina deGiacomo, Jonathan Nasseri, Zhi Chen, Jiaao Xu, Andrea Kovacs – 27 July 2007 – Despite the high frequency of HCV and HIV coinfection, little is known about HCV quasispecies in HIV‐positive patients. The current analysis included 236 HIV+/anti‐HCV+ women enrolled in the Women's Interagency HIV Study (WIHS). Hypervariable region 1 of the second envelope gene was analyzed by single‐strand conformation polymorphism (SSCP).

Katja Derkow, Christoph Loddenkemper, Justine Mintern, Nils Kruse, Katja Klugewitz, Thomas Berg, Bertram Wiedenmann, Hidde L. Ploegh, Eckart Schott – 26 July 2007 – The pathogenesis of autoimmune liver diseases is poorly understood. Animal models are necessary to investigate antigen presentation and priming of T‐cells in the context of autoimmunity in the liver. Transgenic mouse models were generated in which the model antigen ovalbumin is expressed in hepatocytes (TF‐OVA) or cholangiocytes (ASBT‐OVA).

Benoît Rousseau, Ludovic Ménard, Valérie Haurie, Danièle Taras, Jean‐Frédéric Blanc, François Moreau‐Gaudry, Philippe Metzler, Michel Hugues, Sandrine Boyault, Sylvie Lemière, Xavier Canron, Pierre Costet, Michael Cole, Charles Balabaud, Paulette Bioulac‐Sage, Jessica Zucman‐Rossi, Jean Rosenbaum – 26 July 2007 – Using a proteomic analysis of human hepatocellular carcinoma (HCC), we identified the overexpression in 4 tumors of RuvB‐like 2 (RUVBL2), an ATPase and putative DNA helicase known to interact with β‐catenin and cellular v‐myc myelocytomatosis viral oncogene homolog (c‐myc).

Hong‐Lei Weng, Loredana Ciuclan, Yan Liu, Jafar Hamzavi, Patricio Godoy, Haristi Gaitantzi, Stefan Kanzler, Rainer Heuchel, Uwe Ueberham, Rolf Gebhardt, Katja Breitkopf, Steven Dooley – 26 July 2007 – Connective tissue growth factor (CTGF) is important for transforming growth factor‐β (TGF‐β)–induced liver fibrogenesis. Hepatic stellate cells have been recognized as its major cellular source in the liver. Here we demonstrate the induction of CTGF expression in hepatocytes of damaged livers and identify a molecular mechanism responsible for it.

25 July 2007

Maureen M. J. Guichelaar, Jeffrey Schmoll, Michael Malinchoc, J. Eileen Hay – 25 July 2007 – With early posttransplant bone loss, orthotopic liver transplantation (OLT) recipients experience a high rate of fracturing and some avascular necrosis (AVN), but little is known about the incidence of and predictive factors for these skeletal complications.

Puneet Puri, Rebecca A. Baillie, Michelle M. Wiest, Faridoddin Mirshahi, Jayanta Choudhury, Onpan Cheung, Carol Sargeant, Melissa J. Contos, Arun J. Sanyal – 25 July 2007 – The spectrum of nonalcoholic fatty liver disease (NAFLD) includes a nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). The specific types and amounts of lipids that accumulate in NAFLD are not fully defined.

Jordan J. Feld, Melissa Ayers, Dahlia El‐Ashry, Tony Mazzulli, Raymond Tellier, E. Jenny Heathcote – 25 July 2007 – After hepatitis B e antigen (HBeAg) seroconversion, hepatitis B may become inactive or progress to HBeAg‐negative hepatitis with persistent or intermittent alanine aminotransferase (ALT) elevation. The aim of this study was to prospectively identify factors predictive of the clinical course in HBeAg‐negative chronic hepatitis B (CHB). Patients were stratified by ALT and HBeAg status and followed every 3 months for up to 5 years.

Patricia E. Ganey, James P. Luyendyk, Sandra W. Newport, Theresa M. Eagle, Jane F. Maddox, Nigel Mackman, Robert A. Roth – 25 July 2007 – Acetaminophen (N‐acetyl‐p‐aminophenol [APAP]) is one of the leading causes of acute liver failure, and APAP hepatotoxicity is associated with coagulopathy in humans. We tested the hypothesis that activation of the coagulation system and downstream protease‐activated receptor (PAR)‐1 signaling contribute to APAP‐induced liver injury.