Human skin fibroblasts: From mesodermal to hepatocyte‐like differentiation
Philippe A. Lysy, Françoise Smets, Catherine Sibille, Mustapha Najimi, Etienne M. Sokal – 29 October 2007 – The phenotypic homology of fibroblasts and mesenchymal stem cells (MSCs) has been recently described. Our study investigated the in vitro potential of human skin fibroblasts to differentiate into mesodermal (osteocyte and adipocyte) and endodermal (hepatocyte) cell lineages by comparison with human bone marrow (hBM) MSCs. The endodermal potential of fibroblasts was then explored in vivo in a mouse model of liver injury.