Classification and prognosis of intrahepatic biliary stricture after liver transplantation

Hae Won Lee, Kyung‐Suk Suh, Woo Young Shin, Eung‐Ho Cho, Nam‐Joon Yi, Jeong Min Lee, Joon Koo Han, Kuhn Uk Lee – 28 November 2007 – Intrahepatic biliary stricture (IHBS) after liver transplantation (LT) may develop in patients with hepatic artery thrombosis, chronic rejection, or ABO incompatibility, as well as in patients with prolonged warm ischemia in non‐heart‐beating donor (NHBD) LT. However, the clinical course and methods of management have not been well defined for IHBSs to date.

Ischemia‐reperfusion of small liver remnant promotes liver tumor growth and metastases—Activation of cell invasion and migration pathways

Kwan Man, Kevin T. Ng, Chung Mau Lo, Joanna W. Ho, Bai Shun Sun, Chris K. Sun, Terence K. Lee, Ronnie T. P. Poon, Sheung Tat Fan – 28 November 2007 – Elucidating the mechanism of liver tumor growth and metastasis after hepatic ischemia‐reperfusion (I/R) injury of a small liver remnant will lay the foundation for the development of therapeutic strategies to target small liver remnant injury, and will reduce the likelihood of tumor recurrence after major hepatectomy or liver transplantation for liver cancer patients.

Effect of body mass index on the survival benefit of liver transplantation

Shawn J. Pelletier, Douglas E. Schaubel, Guanghui Wei, Michael J. Englesbe, Jeffrey D. Punch, Robert A. Wolfe, Friedrich K. Port, Robert M. Merion – 28 November 2007 – Obese patients are at higher risk for morbidity and mortality after liver transplantation (LT) than nonobese recipients. However, there are no reports assessing the survival benefit of LT according to recipient body mass index (BMI).

Distinct hepatitis C virus core and F protein quasispecies in tumoral and nontumoral hepatocytes isolated via microdissection

Rodolphe Sobesky, Cyrille Feray, François Rimlinger, Nicolas Derian, Alexandre Dos Santos, Anne‐Marie Roque‐Afonso, Didier Samuel, Christian Bréchot, Valérie Thiers – 28 November 2007 – Hepatitis C virus (HCV) genetic variability may be involved in liver carcinogenesis. We investigated HCV core and corresponding putative F protein genetic variability in hepatocellular carcinoma (HCC) and cirrhotic nodules. Hepatocyte clusters from 7 patients with HCC and HCV1b‐related cirrhosis were isolated via microdissection of HCC tissues and 2 nontumoral cirrhotic nodules.

Recurrent hepatic lymphangiomatosis after orthotopic liver transplantation

Seong H. Ra, Robert F. Bradley, Michael C. Fishbein, Ronald W. Busuttil, David S.K. Lu, Charles R. Lassman – 29 October 2007 – Hepatic lymphangiomatosis is a rare disease characterized by an abnormal lymphatic proliferation involving the liver alone, liver and spleen, or multiple organs. Hepatic lymphangiomatosis becomes symptomatic secondary to compression or replacement of the normal parenchyma, which can lead to liver failure. Resection and orthotopic liver transplantation (OLT) can be used as treatment for this disease.

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