The effect of liver transplantation on autonomic dysfunction in patients with end‐stage liver disease

Elizabeth J. Carey, Manjushree Gautam, Timothy Ingall, David D. Douglas – 30 January 2008 – Autonomic dysfunction is a recognized complication of end‐stage liver disease (ESLD), but there is little information on how liver transplantation (LT) affects this problem. We sought to prospectively evaluate autonomic function in patients with ESLD before and after LT. Autonomic reflex screen (ARS) was performed on 30 patients with ESLD prior to transplantation. A 10‐point composite autonomic score (CAS) was calculated from these data.

Polyarteritis nodosa, presenting as life‐threatening gastrointestinal hemorrhage in a liver transplant recipient

Sheldon C. Cooper, Simon P. Olliff, Ian McCafferty, Stephen J. Wigmore, Darius F. Mirza – 30 January 2008 – This unique case reports the first recorded episode in the medical literature of vasculitis post‐liver transplantation, presenting as life‐threatening gastrointestinal hemorrhage. A 52‐year‐old Caucasian woman underwent orthotopic liver transplantation (OLT) for autoimmune cirrhosis complicated by hepatoma and portal vein thrombosis. Late hepatic artery thrombosis led to a second liver graft.

Eighteen years of liver transplantation experience in patients with advanced Budd‐Chiari syndrome

Frank Ulrich, Johann Pratschke, Ulf Neumann, Andreas Pascher, Gero Puhl, Peter Fellmer, Sascha Weiss, Sven Jonas, Peter Neuhaus – 30 January 2008 – The long‐term results of liver transplantation for Budd‐Chiari syndrome (BCS) and timely indication for the procedure are still under debate. Innovations in interventional therapy and better understanding of underlying diseases have improved therapy strategies. The aim of this study was the analysis of patient and disease characteristics, outcome, and specific complications.

Prospective study of liver transplant recipients with HCV infection: Evidence for a causal relationship between HCV and insulin resistance

Aymin Delgado‐Borrego, Yun‐Sheen Liu, Sergio H. Jordan, Saurabh Agrawal, Hui Zhang, Marielle Christofi, Deborah Casson, A. Benedict Cosimi, Raymond T. Chung – 30 January 2008 – An association between hepatitis C virus (HCV) infection and insulin resistance (IR) has been recently reported. However, causality has not been established. The cross‐sectional nature of most reported studies and varying degrees of fibrosis have limited definitive conclusions about the independent role of HCV in development of IR.

Clinicopathological study on cholangiolocellular carcinoma suggesting hepatic progenitor cell origin

Mina Komuta, Bart Spee, Sara Vander Borght, Rita De Vos, Chris Verslype, Raymond Aerts, Hirohisa Yano, Tetsuya Suzuki, Masanori Matsuda, Hideki Fujii, Valeer J. Desmet, Masamichi Kojiro, Tania Roskams – 29 January 2008 – Cholangiolocellular carcinoma (CLC), a subtype of cholangiocellular carcinoma (CC), is thought to originate from the ductules/canals of Hering, where hepatic progenitor cells (HPCs) are located. We investigated the clinicopathological features of 30 CLCs and their relationship to HPCs.

Hepatitis C genotype 4: What we know and what we don't yet know

Sanaa M. Kamal, Imad A. Nasser – 28 January 2008 – Hepatitis C virus genotype 4 (HCV‐4) is the most common variant of the hepatitis C virus (HCV) in the Middle East and Africa, particularly Egypt. This region has the highest prevelance of HCV worldwide, with more than 90% of infections due to genotype 4. HCV‐4 has recently spread in several Western countries, particularly in Europe, due to variations in population structure, immigration, and routes of transmission. The features of HCV‐4 infection and the appropriate therapeutic regimen have not been well characterized.

Subscribe to