A randomized, prospective, pharmacoeconomic trial of neoral 2‐hour postdose concentration monitoring versus tacrolimus trough concentration monitoring in de novo liver transplant recipients
Surendra Shenoy, Karen L. Hardinger, Jeffrey Crippin, Kevin Korenblat, Mauricio Lisker‐Melman, Jeffrey A. Lowell, William Chapman – 30 January 2008 – Two‐hour postdose cyclosporine (C2) monitoring is becoming an accepted method of therapeutic drug monitoring, although it is not known whether C2 monitoring is superior to tacrolimus (FK)‐based immunosuppression. The purpose of this trial was to compare the safety, efficacy, and pharmacoeconomics of cyclosporine A (CsA) monitored by C2 levels versus FK monitored by trough levels in de novo liver transplant recipients.