Fredric D. Gordon, Paul Kwo, Hugo E. Vargas – 28 January 2009 – Recurrent hepatitis C after liver transplantation is a universal phenomenon. Graft reinfection occurs rapidly; once it is established, allograft cirrhosis and decompensation rapidly ensue in many patients. Treatment with pegylated interferon plus ribavirin is the standard of care among nontransplant patients with hepatitis C; however, the applicability of these therapies in liver transplant patients is severely limited.

Veronika Papp, Katalin Dezsö, Viktória László, Peter Nagy, Sándor Paku – 28 January 2009 – Although liver architecture has a major impact on function, morphological aspects of liver growth are relatively neglected. In our recent experiments, the architectural changes of the rat liver were compared during 2 basic processes: ontogeny and regenerative liver growth. The hepatic tissue is constructed as structural/functional units, and probably the most established and well‐defined such unit is the classic lobule.

Sonal Asthana, Glenn K. Bonney, Ashley Guthrie, Mervyn H. Davies, K. Rajendra Prasad – 28 January 2009

Yutaka Midorikawa, Shogo Yamamoto, Shingo Tsuji, Naoko Kamimura, Shumpei Ishikawa, Hisaki Igarashi, Masatoshi Makuuchi, Norihiro Kokudo, Haruhiko Sugimura, Hiroyuki Aburatani – 28 January 2009 – Early hepatocellular carcinoma (eHCC) originates from the hepatocytes of chronic liver disease and develops into classical hepatocellular carcinoma (HCC). To identify sequential genetic changes in multistep hepatocarcinogenesis, we analyzed molecular karyotypes using oligonucleotide genotyping 50K arrays.

Zhi Zhu, Zhigang Luo, Yongmei Li, Canrong Ni, Honghua Li, Minghua Zhu – 28 January 2009 – Inhibitor of growth 1 (ING1) is a type II tumor suppressor that affects cell function by altering chromatin structure and regulating transcription. Recently, three ING1 splice variants have been cloned, but their roles in apoptosis and p53 regulation in human hepatocellular carcinoma (HCC) have not been fully elucidated.

Nicholas J. Hand, Zankhana R. Master, John Le Lay, Joshua R. Friedman – 28 January 2009 – MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression through partial or complete complementarity with target messenger RNAs. The function of miRNAs in normal liver physiology is largely unknown. We address the role of Dicer1 in the differentiated liver. We derived mice lacking Dicer1 function in hepatocytes and assessed the loss of mature miRNA via quantitative polymerase chain reaction.

Gyongyi Szabo – 28 January 2009

Peter Ferenci – 28 January 2009

Hans Tillmann, Keyur Patel, John McHutchison – 28 January 2009

Yusuf Yilmaz, Osman Ozdogan – 28 January 2009