Endoscopic treatment for biliary stricture after adult living donor liver transplantation

Jeong Kyun Seo, Ji Kon Ryu, Sang Hyub Lee, Joo Kyung Park, Ki Young Yang, Yong‐Tae Kim, Yong Bum Yoon, Hae Won Lee, Nam‐Joon Yi, Kyung Suk Suh – 26 March 2009 – Endoscopic intervention is considered to be the primary treatment for biliary stricture after adult living donor liver transplantation (LDLT) with duct‐to‐duct biliary reconstruction. The aim of this study was to investigate the risk factors of biliary stricture and the clinical outcomes and predictors of failure after endoscopic retrograde cholangiography with balloon dilation (ERC‐D).

Pulmonary hypertension after liver transplantation: Case presentation and review of the literature

David G. Koch, Michael Caplan, Adrian Reuben – 26 March 2009 – Hepatopulmonary syndrome and portopulmonary hypertension are the most common pulmonary vascular complications in patients with cirrhosis. Usually but not universally mutually exclusive, they each may present prior to liver transplantation and, if severe enough, may be a contraindication to transplant. However, there have been a number of case reports describing patients developing pulmonary hypertension de novo after liver transplantation.

Killer cell immunoglobulin‐like receptor genotype and killer cell immunoglobulin‐like receptor–human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation

Alejandro Espadas de Arias, Simone Elizabeth Haworth, Luca Saverio Belli, Patrizia Burra, Giovambattista Pinzello, Marcello Vangeli, Ernesto Minola, Maria Guido, Patrizia Boccagni, Tullia Maria De Feo, Rosanna Torelli, Massimo Cardillo, Mario Scalamogna, Francesca Poli – 26 March 2009 – In 20% to 30% of infected individuals, hepatitis C virus (HCV) can cause cirrhosis and hepatocellular carcinoma, for which liver transplantation is the best treatment available.

Effect of angiotensin II and bradykinin inhibition in rat reduced‐size liver transplantation

Susagna Padrissa‐Altés, Rosa Franco‐Gou, Olivier Boillot, Anna Serafín, Antoni Rimola, Vicente Arroyo, Joan Rodés, Carmen Peralta, Joan Roselló‐Catafau – 25 February 2009 – This study examined whether angiotensin II (Ang II) blockers [Ang II type I receptor antagonist, Ang II type II receptor antagonist, and angiotensin converting enzyme (ACE) inhibitor] could reduce hepatic injury and improve regeneration in reduced‐size orthotopic liver transplantation (ROLT) and whether the beneficial effects of ischemic preconditioning (PC) in ROLT could be explained by changes in Ang II.

A re‐evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts

Edward Alabraba, Peter Nightingale, Bridget Gunson, Stefan Hubscher, Simon Olliff, Darius Mirza, James Neuberger – 25 February 2009 – Previously, we have found that the absence of the colon after liver transplantation (LT) protects the patient from recurrent primary sclerosing cholangitis (rPSC). As our previous observation has not been confirmed in other series, we have reviewed our cohort of patients grafted for primary sclerosing cholangitis (PSC) with greater numbers and longer follow‐up to reassess the rate, consequences, and risk factors for rPSC.

Microdialysis monitoring of porcine liver metabolism during warm ischemia with arterial and portal clamping

Johan Ungerstedt, Greg Nowak, Urban Ungerstedt, Bo‐Göran Ericzon – 25 February 2009 – Early detection of vascular complications following liver surgery is crucial. In the present study, intrahepatic microdialysis was used for continuous monitoring of porcine liver metabolism during occlusion of either the portal vein or the hepatic artery. Our aim was to assess whether microdialysis can be used to detect impaired vascular inflow by metabolic changes in the liver. Changes in metabolite concentrations in the hepatic interstitium were taken as markers for metabolic changes.

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