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Letter to the editor: Focus on metabolic dysfunction–associated fatty liver disease, even if patients have a history of excessive alcohol consumption

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Shi‐Tao Jiang, Yi‐Yao Xu, Xin Lu – 10 August 2022

Intrahepatic paracrine signaling by cardiotrophin‐like cytokine factor 1 ameliorates diet‐induced NASH in mice

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Tongyu Liu, Qiuyu Wang, Linkang Zhou, Peng Zhang, Lin Mi, Xiaoxue Qiu, Zhimin Chen, Henry Kuang, Siming Li, Jiandie D. Lin – 10 August 2022

Reply

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Laurens A. Kleef, Robert J. Knegt, Willem Pieter Brouwer – 9 August 2022

Letter to the editor: Fatty liver and mortality in populations who are elderly

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Yanrong Sun, Junwei Zhang, Hanfei Wang, Wenjuan Wang, Huiru Ding, Yiyao Xu, Lihua Qin – 9 August 2022

Sarcopenia, healthy living, and mortality in patients with chronic liver diseases

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Catherine Van Dongen, James M. Paik, Michael Harring, Youssef Younossi, Jillian K. Price, Khaled Kabbara, Pegah Golabi, Zobair M. Younossi – 9 August 2022 – Chronic liver diseases (CLDs) are associated with increased morbidity and mortality. Sarcopenia is an important complication of CLD that can be impacted by several modifiable risk factors. Our aim was to assess the associations between healthy living, sarcopenia, and long‐term outcomes among patients with CLD. We used the Third National Health and Nutrition Examination Survey data with National Death Index–linked mortality files.

Loss of heat shock factor 1 promotes hepatic stellate cell activation and drives liver fibrosis

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Asmita Choudhury, Anuradha Ratna, Arlene Lim, Rebecca M. Sebastian, Christopher L. Moore, Aveline A. Filliol, Jacob Bledsoe, Chengkai Dai, Robert F. Schwabe, Matthew D. Shoulders, Pranoti Mandrekar – 8 August 2022 – Liver fibrosis is an aberrant wound healing response that results from chronic injury and is mediated by hepatocellular death and activation of hepatic stellate cells (HSCs). While induction of oxidative stress is well established in fibrotic livers, there is limited information on stress‐mediated mechanisms of HSC activation.