Benefits of tailored hepatocellular carcinoma screening in patients with cirrhosis on cancer‐specific and overall mortality: A modeling approach

Massih Ningarhari, Abbas Mourad, Claire Delacôte, Line‐Carolle Ntandja Wandji, Guillaume Lassailly, Alexandre Louvet, Sébastien Dharancy, Philippe Mathurin, Sylvie Deuffic‐Burban – 24 August 2022 – To validate cancer screening programs, experts recommend estimating effects on case fatality rates (CFRs) and cancer‐specific mortality. This study evaluates hepatocellular carcinoma (HCC) screening in patients with cirrhosis for those outcomes using a modeling approach.

Incidence of hepatocellular carcinoma in chronic hepatitis B virus infection in those not meeting criteria for antiviral therapy

Omar Alshuwaykh, Tami Daugherty, Amanda Cheung, Aparna Goel, Renumathy Dhanasekaran, T. Tara Ghaziani, Aijaz Ahmed, Deepti Dronamraju, Radhika Kumari, Allison Kwong, Mindie Nguyen, W. Ray Kim, Paul Yien Kwo – 24 August 2022 – Chronic hepatitis B virus (HBV) infection is the leading risk factor for hepatocellular carcinoma (HCC). The aim of this study was to explore the incidence of HCC in a cohort of subjects with HBV and correlate with HBV treatment current guidance. We identified 2846 subjects with HBV over the study period.

β‐catenin cancer–enhancing genomic regions axis is involved in the development of fibrolamellar hepatocellular carcinoma

Ruhi Gulati, Michael Johnston, Maria Rivas, Ashley Cast, Meenasri Kumbaji, Margaret A. Hanlon, Sanghoon Lee, Ping Zhou, Charissa Lake, Emily Schepers, Kyung‐Won Min, Je‐Hyun Yoon, Rebekah Karns, Lola M. Reid, Dolores Lopez‐Terrada, Lubov Timchenko, Sreeja Parameswaran, Matthew T. Weirauch, Sarangarajan Ranganathan, Alexander Bondoc, James Geller, Gregory Tiao, Soona Shin, Nikolai Timchenko – 23 August 2022 – Fibrolamellar hepatocellular carcinoma (FLC) is a disease that occurs in children and young adults.

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